User profiles for Haley M. Geertsma
 | Haley GeertsmaPhD Candidate, University of Ottawa Verified email at uottawa.ca Cited by 16 |
[HTML][HTML] A topographical atlas of α-synuclein dosage and cell type-specific expression in adult mouse brain and peripheral organs
HM Geertsma, ZA Fisk, L Sauline, A Prigent… - npj Parkinson's …, 2024 - nature.com
Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide
and presents pathologically with Lewy pathology and dopaminergic neurodegeneration. …
and presents pathologically with Lewy pathology and dopaminergic neurodegeneration. …
Constitutive nuclear accumulation of endogenous alpha-synuclein in mice causes motor impairment and cortical dysfunction, independent of protein aggregation
A growing body of evidence suggests that nuclear alpha-synuclein (αSyn) plays a role in
the pathogenesis of Parkinson’s disease (PD). However, this question has been difficult to …
the pathogenesis of Parkinson’s disease (PD). However, this question has been difficult to …
[PDF][PDF] Characterizing the differential distribution and targets of Sumo1 and Sumo2 in the mouse brain
…, TT Nguyen, ZA Fisk, M Mitkovski, HM Geertsma… - iScience, 2023 - cell.com
SUMOylation is an evolutionarily conserved eukaryotic posttranslational protein modification
with broad biological relevance. Differentiating between the major small ubiquitin-like …
with broad biological relevance. Differentiating between the major small ubiquitin-like …
[HTML][HTML] Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy
…, B Buchner-Duby, A Bruce, HM Geertsma… - Cell Death & …, 2024 - nature.com
Parkinson’s disease (PD) is a debilitating neurodegenerative disease characterized by the
loss of midbrain dopaminergic neurons (DaNs) and the abnormal accumulation of α-…
loss of midbrain dopaminergic neurons (DaNs) and the abnormal accumulation of α-…
Assessment of Dopaminergic Neurodegeneration in Mice
Neuron death is a key feature of neurological disorders like Alzheimer’s or Parkinson’s disease
(PD). As a result, analysis of neurodegeneration is often considered a central experiment …
(PD). As a result, analysis of neurodegeneration is often considered a central experiment …
Genetic and pharmacological reduction of CDK14 mitigates α-synuclein pathology in human neurons and in rodent models of Parkinson's disease
…, B Buchner-Duby, B Nguyen, A Bruce, HM Geertsma… - bioRxiv, 2022 - biorxiv.org
Parkinsona’s disease (PD) is a debilitating neurodegenerative disease characterized by the
loss of midbrain dopaminergic neurons (DaNs) and the abnormal accumulation of α-…
loss of midbrain dopaminergic neurons (DaNs) and the abnormal accumulation of α-…
Characterizing the differential distribution and targets of Sumo paralogs in the mouse brain
…, TT Nguyen, ZA Fisk, M Mitkovski, HM Geertsma… - bioRxiv, 2022 - biorxiv.org
SUMOylation is an evolutionarily conserved and essential mechanism whereby Small
Ubiquitin Like Modifiers, or SUMO proteins (Sumo in mice), are covalently bound to protein …
Ubiquitin Like Modifiers, or SUMO proteins (Sumo in mice), are covalently bound to protein …
Constitutive nuclear accumulation of endogenous alpha-synuclein in mice causes motor dysfunction and cortical atrophy, independent of protein aggregation
HM Geertsma, TR Suk, KM Ricke, K Horsthuis… - bioRxiv, 2021 - biorxiv.org
Background A growing body of evidence suggests that nuclear alpha-synuclein (αSyn) plays
a role in the pathogenesis of Parkinson’s disease (PD). However, this question has been …
a role in the pathogenesis of Parkinson’s disease (PD). However, this question has been …
[HTML][HTML] Convergent systems-based approaches identify a role for OCIAD1 in Alzheimer's disease
HM Geertsma, MWC Rousseaux - EBioMedicine, 2020 - thelancet.com
Alzheimer’s disease (AD) affects approximately 30À35 million individuals worldwide, posing
a tremendous medical and fiscal burden on society. With life expectancy on the rise, the …
a tremendous medical and fiscal burden on society. With life expectancy on the rise, the …
A topographical atlas of alpha-Synuclein dosage and cell-type expression in the mouse brain and periphery
HM Geertsma, ZA Fisk, L Sauline, A Prigent, K Kurgat… - bioRxiv, 2023 - biorxiv.org
Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide
and presents pathologically with Lewy pathology and dopaminergic neuron loss. Lewy …
and presents pathologically with Lewy pathology and dopaminergic neuron loss. Lewy …
