Alzheimer’s disease (AD) is the most common form of dementia, accounting for 60–70% of
cases in subjects over 65 years of age. Several postulates have been put forward that relate …

The use of human brain tissue obtained at autopsy for neurochemical, pharmacological and
physiological analyses is reviewed. RNA and protein samples have been found suitable for …

In addition, tau (which is a marker of neurofibrillary pathology) colocalized to those same
pyramidal cells that expressed EAAT1. These findings suggest that EAAT1 changes are related …

We have previously shown that the expression of NMDA receptor NR1 subunit mRNA splice
variants in Alzheimer's disease (AD) brain varies according to regional susceptibility to …

It is generally assumed that rodent brains can be used as representative models of neurochemical
function in other species, such as humans. We have compared the distributions of the …

A pathological feature of Alzheimer's disease (AD) is an area-specific neuronal loss that
may be caused by excitotoxicity-related synaptic dysfunction. Relative expression levels of …

We analyzed the expression profile of two NMDAR1 mRNA isoform subsets, NR1 0XX and
NR1 1XX , in discrete regions of human cerebral cortex. The subsets are characterized by the …

Previous work had shown that the ratio of NMDA receptor NR1 subunit mRNA transcripts
containing an N‐terminal splice cassette to those that do not is markedly lower in regions of the …

Cytosolic sulfotransferases are believed to play a role in the neuromodulation of certain
neurotransmitters and drugs. To date, four cytosolic sulfotransferases have been shown to be …

Regionally specific neuronal loss is a distinguishing feature of Alzheimer disease (AD).
Excitotoxicity is a mechanism commonly invoked to explain this. We review the accumulating …