PD-1 is an immunoinhibitory receptor expressed by activated T cells, B cells, and myeloid
cells. Mice deficient in PD-1 exhibit a breakdown of peripheral tolerance and demonstrate …

The potency of oral administration of peptidoglycan (PG) derived from Bifidobacterium
thermophilum was examined. PG was administered to kuruma shrimps through the diet at 0.2 mg/…

PD-1, a 55 kDa transmembrane protein containing an immunoreceptor tyrosine-based inhibitory
motif, is induced in lymphocytes and monocytic cells following activation. Aged C57BL/6…

Dilated cardiomyopathy is a severe pathology of the heart with poorly understood etiology.
Disruption of the gene encoding the negative immunoregulatory receptor PD-1 in BALB/c …

Programmed death 1 (PD-1)–deficient mice develop a variety of autoimmune-like diseases,
which suggests that this immunoinhibitory receptor plays an important role in tolerance. We …

A mAb J43 has been produced against the product of the mouse PD-1 gene, a member of
the Ig gene superfamily, which was previously isolated from an apoptosis-induced T cell …

Thrombo-occlusive cerebrovascular disease resulting in stroke and permanent neuronal
loss is an important cause of morbidity and mortality. Because of the unique properties of …

PD-1 is an immunoreceptor that belongs to the immunoglobulin (Ig) superfamily and contains
two tyrosine residues in the cytoplasmic region. Studies on PD-1-deficient mice have …

PD-1, an Ig superfamily member, contains an immunoreceptor tyrosine-based inhibitory motif
in the cytoplasmic tail. It is expressed in a minor fraction of CD4-CD8- normal thymocytes …

PD-1 deficiency causes a variety of autoimmune diseases. Inhibitory signaling through the
PD-1 receptor might therefore be involved in the regulation of peripheral tolerance. The …