Topoisomerases are expressed throughout the developing and adult brain and are mutated
in some individuals with autism spectrum disorder (ASD). However, how topoisomerases …

The 67 and 65 kDa isoforms of glutamic acid decarboxylase, the key enzymes for GABA
biosynthesis, are expressed at altered levels in postmortem brain of subjects diagnosed with …

Alterations in GABAergic mRNA expression play a key role for prefrontal dysfunction in
schizophrenia and other neurodevelopmental disease. Here, we show that histone H3-lysine 4 …

Angelman syndrome is a severe neurodevelopmental disorder caused by deletion or mutation
of the maternal allele of the ubiquitin protein ligase E3A (UBE3A) 1 , 2 , 3 . In neurons, the …

Expression of brain-derived neurotrophic factor (BDNF) is developmentally regulated in
prefrontal cortex (PFC). The underlying molecular mechanisms, however, remain unclear. Here, …

BACKGROUND: Prefrontal deficits in gamma-aminobutyric acid (GABA)ergic gene expression,
including neuropeptide Y (NPY), somatostatin (SST), and parvalbumin (PV) messenger …

Dysfunction of prefrontal cortex in schizophrenia includes changes in GABAergic mRNAs,
including decreased expression of GAD1, encoding the 67 kDa glutamate decarboxylase (…

Alterations in RNA levels are frequently reported in brain of subjects diagnosed with autism,
schizophrenia, depression, and other psychiatric diseases, but it remains unclear whether …

Background DNA-protein interactions in mature brain are increasingly recognized as key
regulators for behavioral plasticity and neuronal dysfunction in chronic neuropsychiatric …

Angelman syndrome (AS) is a severe neurodevelopmental disorder associated with disruption
of maternally inherited UBE3A (ubiquitin protein ligase E3A) expression. At the present …