[HTML][HTML] Serum microRNA profiles in children with autism

M Mundalil Vasu, A Anitha, I Thanseem, K Suzuki… - Molecular autism, 2014 - Springer
Background As regulators of gene expression, microRNAs (miRNAs) play a key role in the
transcriptional networks of the developing human brain. Circulating miRNAs in the serum and …

[HTML][HTML] Brain region-specific altered expression and association of mitochondria-related genes in autism

A Anitha, K Nakamura, I Thanseem, K Yamada… - Molecular autism, 2012 - Springer
Background Mitochondrial dysfunction (MtD) has been observed in approximately five
percent of children with autism spectrum disorders (ASD). MtD could impair highly energy-…

Downregulation of the expression of mitochondrial electron transport complex genes in autism brains

A Anitha, K Nakamura, I Thanseem… - Brain …, 2013 - Wiley Online Library
Mitochondrial dysfunction ( MtD ) and abnormal brain bioenergetics have been implicated
in autism, suggesting possible candidate genes in the electron transport chain ( ETC ). We …

[HTML][HTML] Genetic affinities among the lower castes and tribal groups of India: inference from Y chromosome and mitochondrial DNA

I Thanseem, K Thangaraj, G Chaubey, VK Singh… - BMC genetics, 2006 - Springer
Background India is a country with enormous social and cultural diversity due to its positioning
on the crossroads of many historic and pre-historic human migrations. The hierarchical …

[HTML][HTML] In situ origin of deep rooting lineages of mitochondrial Macrohaplogroup 'M' in India

…, G Chaubey, VK Singh, A Vanniarajan, I Thanseem… - BMC genomics, 2006 - Springer
Background Macrohaplogroups 'M' and 'N' have evolved almost in parallel from a founder
haplogroup L3. Macrohaplogroup N in India has already been defined in previous studies and …

[HTML][HTML] Decreased expression of axon-guidance receptors in the anterior cingulate cortex in autism

…, C Shimmura, Y Kameno, A Anitha, I Thanseem… - Molecular autism, 2011 - Springer
Background Axon-guidance proteins play a crucial role in brain development. As the dysfunction
of axon-guidance signaling is thought to underlie the microstructural abnormalities of …

Genetic analyses of Roundabout (ROBO) axon guidance receptors in autism

…, K Yamada, S Suda, I Thanseem… - American Journal of …, 2008 - Wiley Online Library
Autism is a pervasive developmental disorder diagnosed in early childhood. Abnormalities
of serotonergic neurotransmission have been reported in autism. Serotonin transporter (SERT…

Protocadherin α (PCDHA) as a novel susceptibility gene for autism

A Anitha, I Thanseem, K Nakamura, K Yamada… - Journal of Psychiatry and …, 2013 - jpn.ca
Background: Synaptic dysfunction has been shown to be involved in the pathogenesis of
autism. We hypothesized that the protocadherin α gene cluster (PCDHA), which is involved in …

miRNAs as biomarkers of neurodegenerative disorders

V Viswambharan, I Thanseem, MM Vasu… - Biomarkers in …, 2017 - Future Medicine
Neurodegenerative diseases (NDDs) are the result of progressive deterioration of neurons,
ultimately leading to disabilities. There is no effective cure for NDDs at present; ongoing …

Telomeres in neurological disorders

A Anitha, I Thanseem, MM Vasu… - Advances in Clinical …, 2019 - Elsevier
Ever since their discovery, the telomeres and the telomerase have been topics of intensive
research, first as a mechanism of cellular aging and later as an indicator of health and …