Itraconazole (R 51211) is the prototype of a class of triazole antifungals characterized by a
high lipophilicity. This property determines to a large extent the pharmacokinetics of …

IN the search for compounds active against human immunodeficiency virus (HIV), we have
found that members of a novel series of tetrahydro-imidazo[4,5,1-jk][l,4]-benzodiazepin-2(1H)-…

The pharmacokinetics of a novel antipsychotic agent, risperidone, and the prolactin response
were studied in 12 dextromethorphan‐phenotyped healthy men after administration of 1 …

Ovine fascioliasis is a major economical problem in Great Britain, Australia, New Zealand,
South Africa, and many other sheep-rearing countries. Fasciola hepatica causes considerable …

The absorption, metabolism, and excretion of the novel antipsychotic risperidone was
studied in three healthy male subjects. One week after a single oral dose of 1 mg [14C]risperidone, …

Itraconazole is an orally effective antifungal agent with a high affinity for tissues. The skin
kinetics in human volunteers have been studied after administration of 100 and 200 mg of …

The pharmacokinetics of itraconazole in animals and man are reviewed and compared with
those of ketoconazole. The physicochemical properties of itraconazole, assay methods and …

The pharmacokinetics of sufentanil, a new thienyl analogue of fentanyl, were studied in 10
surgical patients. Sufentanil, 5 micrograms/kg, was given intravenously as a bolus injection …

The in vitro plasma protein binding and distribution in blood of fentanyl and three analogues
were studied in rats, dogs and healthy volunteers. In human plasma, 84.4% of fentanyl was …

Background The pharmacokinetic profiles of sufentanil available in the literature are conflicting
because of methodologic differences. Length of sampling and assay sensitivity are key …