Pathological alterations to the locus coeruleus, the major source of noradrenaline in the
brain, are histologically evident in early stages of neurodegenerative diseases. Novel MRI …

Inflammation is increasingly implicated as a risk factor for dementia, stroke, and small vessel
disease (SVD). However, the underlying mechanisms and causative pathways remain …

… James Rowe is in receipt of research grants from AZ-Medimmune and Janssen; with principal
funding from the Wellcome Trust, Medical Research Council, and the National Institute for …

Background: PSP is a neuropathologically defined disease entity. Clinical diagnostic criteria,
published in 1996 by the National Institute of Neurological Disorders and Stroke/Society for …

It is controversial whether the dorsolateral prefrontal cortex is involved in the maintenance of
items in working memory or in the selection of responses. We used event-related functional …

Little is known about the underlying neurobiology of rhythm and beat perception, despite its
universal cultural importance. Here we used functional magnetic resonance imaging to study …

Background Frontotemporal dementia is a highly heritable neurodegenerative disorder. In
about a third of patients, the disease is caused by autosomal dominant genetic mutations …

Objectives: To estimate the lifetime risk, prevalence, incidence, and mortality of the principal
clinical syndromes associated with frontotemporal lobar degeneration (FTLD) using revised …

Background As greater numbers of us are living longer, it is increasingly important to understand
how we can age healthily. Although old age is often stereotyped as a time of declining …

… Rowe was involved with data acquisition and reviewed the manuscript. Prof. Mollenhauer
is … Rowe is supported by the Wellcome Trust (088324), Medical Research Council, NIHR, …