Brain development and function depend on the precise regulation of gene expression.
However, our understanding of the complexity and dynamics of the transcriptome of the human …

Catechol-O-methyltransferase (COMT) is a key enzyme in the elimination of dopamine in the
prefrontal cortex of the human brain. Genetic variation in the COMT gene (MIM 116790) has …

Recent advances in 3D culture systems have led to the generation of brain organoids that
resemble different human brain regions; however, a 3D organoid model of the midbrain …

Previous investigations have combined transcriptional and genetic analyses in human cell
lines 1 , 2 , 3 , but few have applied these techniques to human neural tissue 4 , 5 , 6 , 7 , 8 . …

Anatomical and molecular abnormalities of excitatory neurons in the dorsolateral prefrontal
cortex (DLPFC) are found in schizophrenia. We hypothesized that brain-derived neurotrophic …

INTRODUCTION The brain is responsible for cognition, behavior, and much of what makes
us uniquely human. The development of the brain is a highly complex process, and this …

Recent advances in communication and sensor technology have catalyzed progress in
remote monitoring capabilities for water quality. As a result, the ability to characterize dynamic …

Background: Schizophrenia has been hypothesized to be caused by a hypofunction of
glutamatergic neurons. Findings of reduced concentrations of glutamate in the cerebrospinal fluid …

GRM3, a metabotropic glutamate receptor-modulating synaptic glutamate, is a promising
schizophrenia candidate gene. In a family-based association study, a common GRM3 …

Catechol O-methyltransferase (COMT) is involved in the inactivation of catecholamines,
including the neurotransmitter dopamine. A Val 108/158 Met functional polymorphism of the …