Zn 2+ is the second most prevalent trace element in the body and is present in particularly
large concentrations in the mammalian brain. Although Zn 2+ is a cofactor for many enzymes …

Compelling evidence supports contributions of glutamate receptor overactivation (‘excitotoxicity’)
to neurodegeneration in both acute conditions, such as stroke, and chronic …

Neurological diseases, including global ischemia, Alzheimer's disease and amyotrophic
lateral sclerosis, are characterized by selective patterns of neurodegeneration. Most studies of …

The nonphosphorylated neurofilament marker SMI-32 stains motor neurons in spinal cord
slices and stains a subset of cultured spinal neurons [“large SMI-32(+) neurons”], which have …

Synaptically released Zn 2+ can enter and cause injury to postsynaptic neurons. Microfluorimetric
studies using the Zn 2+ -sensitive probe, Newport green, examined levels of [Zn 2+ ] i …

Recent evidence suggests that intracellular Zn 2+ accumulation contributes to the neuronal
injury that occurs in epilepsy or ischemia in certain brain regions, including hippocampus, …

The reason for the selective vulnerability of motor neurons in amyotrophic lateral sclerosis (ALS)
is primarily unknown. A possible factor is the expression by motor neurons of Ca 2+ -…

Murine neuronal and glial cell cultures exposed briefly to glutamate accumulated large amounts
of 45Ca2+ from the extracellular medium during the exposure. Most of the accumulation …

New fluorescent indicators with nanomolar to micromolar affinities for Zn 2+ have been
synthesized in wavelengths from UV to the far red. The UV light-excited indicators are ratiometric. …

Rapid entry of Ca 2+ or Zn 2+ kills neurons. Mitochondria are major sites of Ca 2+ -dependent
toxicity. This study examines Zn 2+ -initiated mitochondrial cell death signaling. 10 nm Zn …