Background: This report provides histopathological evidence to support prior neuroimaging
findings of decreased volume and altered metabolism in the frontal cortex in major …

BACKGROUND: Imaging studies report that hippocampal volume is decreased in major
depressive disorder (MDD). A cellular basis for reduced hippocampal volume in MDD has not …

The norepinephrine transporter (NET) is a membrane protein responsible for termination of
the action of synaptic norepinephrine and is a site of action of many drugs used to treat major …

OBJECTIVE: Self-esteem can play an important role in suicidal tendencies among
adolescents. The present study was designed to examine the relationship between self-esteem …

Humor can provide a method of coping with a variety of stressful situations. Unfortunately,
the scientific measurement of humor has suffered from many methodological problems, …

Major depressive disorder (MDD) has been linked to changes in function and activity of the
hippocampus, one of the central limbic regions involved in regulation of emotions and mood. …

Background: Recent postmortem studies in major depressive disorder (MDD) provide evidence
for a reduction in the packing density and number of glial cells in different regions of the …

RNA encoding the human serotonin 5-HT 2C receptor (5-HT 2C R) undergoes adenosine-to-inosine
RNA editing events at five positions, resulting in an alteration of amino acids in the …

… Correspondence concerning this article should be addressed to James C. Overholser,
Department of Psychology, Case Western Reserve University, Cleveland, OH 44106 …

The present study was designed to examine depression, hopelessness, and self‐esteem as
related to suicidal behavior in three groups of depressed adolescent psychiatric inpatients. …