Schizophrenia is a chronic and disabling brain disease characterized by psychotic
episodes with unknown etiology. It is suggested that neuroinflammation plays a role in the …

Brain-derived neurotrophic factor (BDNF) is one of the most studied neurotrophins in the
healthy and diseased brain. As a result, there is a large body of evidence that associates BDNF …

Review on the key role for activated microglia and monocytes in the pathogenesis of bipolar
disorder and schizophrenia. This review describes a key role for mononuclear phagocytes …

Major depressive disorder (MDD) is a prevalent and disabling psychiatric disease with rates
of non-responsiveness to antidepressants ranging from 30–50%. Historically, the …

Background: The “monocyte-T-cell theory of mood disorders” regards neuroinflammation, ie
marked activation of microglia, as a driving force in bipolar disorder. Microglia activation can …

Chronic neuroinflammation, which is primarily mediated by microglia, plays an essential
role in aging and neurodegeneration. It is still unclear whether this microglia-induced …

Schizophrenia is a heterogeneous psychiatric disorder, which can severely impact social and
professional functioning. Epidemiological and clinical studies show that schizophrenia has …

Background Activation of microglia cells plays an important role in neurological diseases.
Positron emission tomography (PET) with [ 11 C]-(R)-PK11195 has already been used to …

High-resolution anatomical image data in preclinical brain PET and SPECT studies is often
not available, and inter-modality spatial normalization to an MRI brain template is frequently …

It is important to gain more insight into neurodegenerative diseases, because these debilitating
diseases can not be cured. A common characteristic of many neurological diseases is …