User profiles for Jason P. Lerch

Jason Lerch

Wellcome Centre for Integrative Neuroimaging, University of Oxford
Verified email at ndcn.ox.ac.uk
Cited by 41786

Neurodevelopmental trajectories of the human cerebral cortex

P Shaw, NJ Kabani, JP Lerch, K Eckstrand… - Journal of …, 2008 - Soc Neuroscience
Understanding the organization of the cerebral cortex remains a central focus of neuroscience.
Cortical maps have relied almost exclusively on the examination of postmortem tissue to …

Cortical thickness analysis examined through power analysis and a population simulation

JP Lerch, AC Evans - Neuroimage, 2005 - Elsevier
We have previously developed a procedure for measuring the thickness of cerebral cortex
over the whole brain using 3-D MRI data and a fully automated surface-extraction (ASP) …

[PDF][PDF] Behavioral phenotypes of Disc1 missense mutations in mice

…, JK Millar, S Mackie, S Christie, F Ogawa, JP Lerch… - Neuron, 2007 - cell.com
To support the role of DISC1 in human psychiatric disorders, we identified and analyzed two
independently derived ENU-induced mutations in Exon 2 of mouse Disc1. Mice with …

Structural asymmetries in the human brain: a voxel-based statistical analysis of 142 MRI scans

…, JP Lerch, A Zijdenbos, DL Collins, P Neelin… - Cerebral …, 2001 - academic.oup.com
The use of computational approaches in the analysis of highresolution magnetic resonance
images (MRI) of the human brain provides a powerful tool for in vivo studies of brain anatomy…

Mapping anatomical correlations across cerebral cortex (MACACC) using cortical thickness from MRI

JP Lerch, K Worsley, WP Shaw, DK Greenstein… - Neuroimage, 2006 - Elsevier
We introduce MACACC-Mapping Anatomical Correlations Across Cerebral Cortex-to study
correlated changes within and across different cortical networks. The principal topic of …

High resolution three-dimensional brain atlas using an average magnetic resonance image of 40 adult C57Bl/6J mice

AE Dorr, JP Lerch, S Spring, N Kabani, RM Henkelman - Neuroimage, 2008 - Elsevier
Detailed anatomical atlases can provide considerable interpretive power in studies of both
human and rodent neuroanatomy. Here we describe a three-dimensional atlas of the mouse …

Neuroanatomical correlates of musicianship as revealed by cortical thickness and voxel-based morphometry

P Bermudez, JP Lerch, AC Evans, RJ Zatorre - Cerebral cortex, 2009 - academic.oup.com
We used a multimethod approach to investigate the neuroanatomical correlates of musicianship
and absolute pitch (AP). Cortical thickness measures, interregional correlations applied …

Focal decline of cortical thickness in Alzheimer's disease identified by computational neuroanatomy

JP Lerch, JC Pruessner, A Zijdenbos, H Hampel… - Cerebral …, 2005 - academic.oup.com
Alzheimer's disease (AD) is characterized by a heterogeneous distribution of pathological
changes throughout the brain. Magnetic resonance imaging can be used to investigate the …

Spatial patterns of cortical thinning in mild cognitive impairment and Alzheimer's disease

V Singh, H Chertkow, JP Lerch, AC Evans, AE Dorr… - Brain, 2006 - academic.oup.com
… pole than those seen in the Lerch study. The overall pattern of … Lerch study were marginally
more severe in terms of their MMSE scores. Nevertheless, the age distribution in the Lerch

Performing label‐fusion‐based segmentation using multiple automatically generated templates

…, A Raznahan, DL Collins, JP Lerch - Human brain …, 2013 - Wiley Online Library
Classically, model‐based segmentation procedures match magnetic resonance imaging (MRI)
volumes to an expertly labeled atlas using nonlinear registration. The accuracy of these …