User profiles for Javier DeFelipe

Javier DeFelipe

Instituto Cajal (CSIC) and Universidad Politécnica de Madrid, Spain
Verified email at cajal.csic.es
Cited by 30226

[PDF][PDF] Reconstruction and simulation of neocortical microcircuitry

…, JV Díaz, R Walker, Y Wang, SM Zaninetta, J DeFelipe… - Cell, 2015 - cell.com
We present a first-draft digital reconstruction of the microcircuitry of somatosensory cortex of
juvenile rat. The reconstruction uses cellular and synaptic organizing principles to …

The pyramidal neuron of the cerebral cortex: morphological and chemical characteristics of the synaptic inputs

J DeFelipe, I Fariñas - Progress in neurobiology, 1992 - Elsevier
4.3. 1.1. Other pyramidal cells 4.3. 1.2. Spiny nonpyramidal neurons 4.3. 1.3. Aspiny nonpyramidal
neurons 4.3. 2. Cortical afferent systems 4.3. 2.1. Thalamocortical afferent fibers 4.3. …

Microstructure of the neocortex: comparative aspects

J DeFelipe, L Alonso-Nanclares, JI Arellano - Journal of neurocytology, 2002 - Springer
The appearance of the neocortex, its expansion, and its differentiation in mammals,
represents one of the principal episodes in the evolution of the vertebrate brain. One of the …

Chandelier cells and epilepsy

J DeFelipe - Brain, 1999 - academic.oup.com
The main goal of this article is to review certain aspects of the circuitry of the human cerebral
cortex that may be particularly relevant for the development, maintenance or spread of …

From the connectome to the synaptome: an epic love story

J DeFelipe - science, 2010 - science.org
A major challenge in neuroscience is to decipher the structural layout of the brain. The term “connectome”
has recently been proposed to refer to the highly organized connection matrix …

New insights into the classification and nomenclature of cortical GABAergic interneurons

J DeFelipe, PL López-Cruz… - Nature Reviews …, 2013 - nature.com
A systematic classification and accepted nomenclature of neuron types is much needed but
is currently lacking. This article describes a possible taxonomical solution for classifying …

Types of neurons, synaptic connections and chemical characteristics of cells immunoreactive for calbindin-D28K, parvalbumin and calretinin in the neocortex

J DeFelipe - Journal of chemical neuroanatomy, 1997 - Elsevier
This article provides a general account of types of neurons, synaptic connections and chemical
characteristics (colocalization studies) of cells immunoreactive for the three main calcium-…

[HTML][HTML] The evolution of the brain, the human nature of cortical circuits, and intellectual creativity

J DeFelipe - Frontiers in neuroanatomy, 2011 - frontiersin.org
The tremendous expansion and the differentiation of the neocortex constitute two major
events in the evolution of the mammalian brain. The increase in size and complexity of our …

[HTML][HTML] Ultrastructure of dendritic spines: correlation between synaptic and spine morphologies

JI Arellano, R Benavides-Piccione, J DeFelipe… - Frontiers in …, 2007 - frontiersin.org
Dendritic spines are critical elements of cortical circuits, since they establish most excitatory
synapses. Recent studies have reported correlations between morphological and functional …

Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects

…, DF O'brien, RM Conroy, RL Stallings, J DeFelipe… - Nature medicine, 2012 - nature.com
Temporal lobe epilepsy is a common, chronic neurological disorder characterized by recurrent
spontaneous seizures. MicroRNAs (miRNAs) are small, noncoding RNAs that regulate …