Introduction Vortioxetine is a multimodal-acting antidepressant that provides improvements
on cognitive function aside from antidepressants and anxiolytic effects. Vortioxetine has been …

Deep brain stimulation (DBS) is currently tested as an experimental therapy for patients with
treatment-resistant depression (TRD). Here we report on the short- and long-term (1 yr) …

Background A 12-week, double-blind, parallel, multi-center randomized controlled trial in
316 adult patients with major depressive disorder (MDD) was conducted to evaluate the …

BACKGROUND: Few studies have addressed the implication of the duration of untreated
illness (DUI) on the clinical outcome of mood disorders. Although not focusing on DUI, previous …

Background: To date, antidepressant drugs show limited efficacy, leaving a large number of
patients experiencing severe and persistent symptoms of major depression. Previous open-…

Structural and neuropathological alterations in the ventromedial prefrontal cortex (vmPFC)
described in depression (MDD) might become even more pronounced over the course of …

Objective: Since depression entails not only dramatic personal disruption but also a huge
amount of medical and socioeconomic burden, slowness of antidepressant action and …

… de Diego-Adeliño is funded by the Instituto de Salud Carlos III through a “Rio Hortega” research
fellowship. MJ Portella is funded by the Ministerio de … de Diego-Adeliño and MJ Portella …

Although alterations in the gut microbiota have been linked to the pathophysiology of major
depressive disorder (MDD), including through effects on the immune response, our …

BackgroundFindings of brain structural changes in major depressive disorder are still
inconsistent, partly because some crucial clinical variables have not been taken into account.…