User profiles for Jean-Francois Theroux
 | Jean ThérouxMurdoch University Verified email at murdoch.edu.au Cited by 1822 |
Single-nucleus transcriptomics of the prefrontal cortex in major depressive disorder implicates oligodendrocyte precursor cells and excitatory neurons
Major depressive disorder (MDD) has an enormous impact on global disease burden, affecting
millions of people worldwide and ranking as a leading cause of disability for almost three …
millions of people worldwide and ranking as a leading cause of disability for almost three …
Association of a history of child abuse with impaired myelination in the anterior cingulate cortex: convergent epigenetic, transcriptional, and morphological evidence
Objective: Child abuse has devastating and long-lasting consequences, considerably
increasing the lifetime risk of negative mental health outcomes such as depression and suicide. …
increasing the lifetime risk of negative mental health outcomes such as depression and suicide. …
Neurons diversify astrocytes in the adult brain through sonic hedgehog signaling
Astrocytes are specialized and heterogeneous cells that contribute to central nervous system
function and homeostasis. However, the mechanisms that create and maintain differences …
function and homeostasis. However, the mechanisms that create and maintain differences …
A dual noradrenergic mechanism for the relief of neuropathic allodynia by the antidepressant drugs duloxetine and amitriptyline
In addition to treating depression, antidepressant drugs are also a first-line treatment for
neuropathic pain, which is pain secondary to lesion or pathology of the nervous system. Despite …
neuropathic pain, which is pain secondary to lesion or pathology of the nervous system. Despite …
miR-323a regulates ERBB4 and is involved in depression
Major depressive disorder (MDD) is a complex and debilitating illness whose etiology remains
unclear. Small RNA molecules, such as micro RNAs (miRNAs) have been implicated in …
unclear. Small RNA molecules, such as micro RNAs (miRNAs) have been implicated in …
[HTML][HTML] GPR56/ADGRG1 is associated with response to antidepressant treatment
R Belzeaux, V Gorgievski, LM Fiori, JP Lopez… - Nature …, 2020 - nature.com
It remains unclear why many patients with depression do not respond to antidepressant
treatment. In three cohorts of individuals with depression and treated with serotonin-…
treatment. In three cohorts of individuals with depression and treated with serotonin-…
Neuron-derived extracellular vesicles enriched from plasma show altered size and miRNA cargo as a function of antidepressant drug response
Previous work has demonstrated that microRNAs (miRNAs) change as a function of
antidepressant treatment (ADT) response. However, it is unclear how representative these …
antidepressant treatment (ADT) response. However, it is unclear how representative these …
[PDF][PDF] Mutations in ACTL6B cause neurodevelopmental deficits and epilepsy and lead to loss of dendrites in human neurons
…, H Peng, Z Aouabed, P Priam, JF Theroux… - The American Journal of …, 2019 - cell.com
We identified individuals with variations in ACTL6B, a component of the chromatin remodeling
machinery including the BAF complex. Ten individuals harbored bi-allelic mutations and …
machinery including the BAF complex. Ten individuals harbored bi-allelic mutations and …
Evidence of decreased gap junction coupling between astrocytes and oligodendrocytes in the anterior cingulate cortex of depressed suicides
Glial dysfunction is a major pathophysiological feature of mood disorders. While altered
astrocyte (AS) and oligodendrocyte-lineage (OL) functions have been associated with …
astrocyte (AS) and oligodendrocyte-lineage (OL) functions have been associated with …
[PDF][PDF] Disruption of GRIN2B impairs differentiation in human neurons
S Bell, G Maussion, M Jefri, H Peng, JF Theroux… - Stem Cell Reports, 2018 - cell.com
Heterozygous loss-of-function mutations in GRIN2B, a subunit of the NMDA receptor, cause
intellectual disability and language impairment. We developed clonal models of GRIN2B …
intellectual disability and language impairment. We developed clonal models of GRIN2B …