User profiles for Jean-Louis A. Parmasad
 | Jean-Louis A ParmasadUniversity of Ottawa Verified email at uottawa.ca Cited by 14 |
Constitutive nuclear accumulation of endogenous alpha-synuclein in mice causes motor impairment and cortical dysfunction, independent of protein aggregation
…, KM Ricke, K Horsthuis, JLA Parmasad… - Human Molecular …, 2022 - academic.oup.com
A growing body of evidence suggests that nuclear alpha-synuclein (αSyn) plays a role in
the pathogenesis of Parkinson’s disease (PD). However, this question has been difficult to …
the pathogenesis of Parkinson’s disease (PD). However, this question has been difficult to …
[PDF][PDF] Characterizing the differential distribution and targets of Sumo1 and Sumo2 in the mouse brain
SUMOylation is an evolutionarily conserved eukaryotic posttranslational protein modification
with broad biological relevance. Differentiating between the major small ubiquitin-like …
with broad biological relevance. Differentiating between the major small ubiquitin-like …
[HTML][HTML] Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy
Parkinson’s disease (PD) is a debilitating neurodegenerative disease characterized by the
loss of midbrain dopaminergic neurons (DaNs) and the abnormal accumulation of α-…
loss of midbrain dopaminergic neurons (DaNs) and the abnormal accumulation of α-…
Genetic and pharmacological reduction of CDK14 mitigates α-synuclein pathology in human neurons and in rodent models of Parkinson's disease
JLA Parmasad, KM Ricke, MG Stykel, B Buchner-Duby… - bioRxiv, 2022 - biorxiv.org
Parkinsona’s disease (PD) is a debilitating neurodegenerative disease characterized by the
loss of midbrain dopaminergic neurons (DaNs) and the abnormal accumulation of α-…
loss of midbrain dopaminergic neurons (DaNs) and the abnormal accumulation of α-…
Characterizing the differential distribution and targets of Sumo paralogs in the mouse brain
…, ZA Fisk, M Mitkovski, HM Geertsma, JLA Parmasad… - bioRxiv, 2022 - biorxiv.org
SUMOylation is an evolutionarily conserved and essential mechanism whereby Small
Ubiquitin Like Modifiers, or SUMO proteins (Sumo in mice), are covalently bound to protein …
Ubiquitin Like Modifiers, or SUMO proteins (Sumo in mice), are covalently bound to protein …
Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy
MWC Rousseaux, JL Parmasad, K Ricke, M Stykel… - 2023 - researchsquare.com
Parkinson's disease (PD) is a debilitating neurodegenerative disease characterized by the
loss of midbrain dopaminergic neurons (DaNs) and the abnormal accumulation of α-…
loss of midbrain dopaminergic neurons (DaNs) and the abnormal accumulation of α-…
Constitutive nuclear accumulation of endogenous alpha-synuclein in mice causes motor dysfunction and cortical atrophy, independent of protein aggregation
…, TR Suk, KM Ricke, K Horsthuis, JLA Parmasad… - bioRxiv, 2021 - biorxiv.org
Background A growing body of evidence suggests that nuclear alpha-synuclein (αSyn) plays
a role in the pathogenesis of Parkinson’s disease (PD). However, this question has been …
a role in the pathogenesis of Parkinson’s disease (PD). However, this question has been …
alpha-Synuclein pre-formed fibrils preparation and stereotactic injection into Mus Musculus brain
JL Parmasad - 2024 - slack.protocols.io
Preparation of seed-competent alpha-Synuclein pre-formed fibrils and subsequent
stereotactic injection into Mus Musculus brain as a model of synucleinopathy.
stereotactic injection into Mus Musculus brain as a model of synucleinopathy.
Young Researchers' Brain Health Research Day Joint ConferenceEffect of prior treatment history and sex on antidepressant response to subanesthetic ketamine …
Background Only 35% of patients with major depressive disorder remit after first-line
treatment on medications with antidepressant properties. Furthermore, sex differences in …
treatment on medications with antidepressant properties. Furthermore, sex differences in …
2020-2021 IgNITE Medical Case Competition: Regenerative Medicine
D Bojic, B Bezuidenhout, H Gill - … in Natural and Clinical Science and …, 2021 - urncst.com
The IgNITE Medical Case Competition is an annual research case competition organized
by students at the University of Ottawa. Our mission is to provide high school and university …
by students at the University of Ottawa. Our mission is to provide high school and university …
