BACKGROUND: Major depression (MD) has been associated with increased cardiovascular
mortality in patients with coronary heart disease (CHD) and has been described as an …

1. Neuroactive steroids are steroid hormones that exert rapid, nongenomic effects at ligand-gated
ion channels. There is increasing awareness of the possible role of these steroids in …

Although major depression (MD) and cardiovascular disease (CVD) have been conclusively
linked in the literature, the mechanism associating MD and CVD is yet undetermined. The …

It remains unexplained why a greater prevalence of anxiety disorders exists in women than
in men, and how female hormone-related events (ie, menstrual cycle and postpartum) can …

The classic mechanism of action of steroid hormones involves binding to their respective
intracellular receptors, which act as transcription factors in the regulation of gene expression. …

BACKGROUND: Women who suffer from premenstrual dysphoric disorder (PMDD) classically
display depressive and anxiety symptoms in the premenstrum. Preclinical and clinical …

Objective: To investigate the frequency of gambling in people who have been diagnosed
with major depressive disorder (MDD) or bipolar disorder (BD). Secondary objectives were to …

Serum levels of allopregnanolone, pregnenolone sulfate, and dehydroepiandrosterone sulfate
were measured in 8 male patients with generalized anxiety disorder (GAD) and 8 healthy …

Rationale It has been suggested that endothelial dysfunction caused by a decreased
endothelial production of nitric oxide (NO) may contribute to the consistently observed increased …

Background. Animal studies have shown that neuroactive steroids modulate the activity of
the gamma-aminobutyric acid type A/benzodiazepine receptor complex and that these …