The purpose of this study was to characterize a new chemical entity, desvenlafaxine succinate
(DVS). DVS is a novel salt form of the isolated major active metabolite of venlafaxine. …

Purpose: A dose and volume limiting factor in radiation treatment of thoracic cancer is the
development of fibrosis in normal lung. The goal of the present study was to determine whether …

Esophagitis is a major toxicity of radiation therapy for nonsmall‐cell lung cancer. Intraesophageal
injection of manganese superoxide dismutase (MnSOD) plasmid/liposome complexes (…

Progesterone (P4) is an essential reproductive steroid hormone required for many aspects of
female reproductive physiology. Progestins are compounds that demonstrate progesterone-…

The discovery of a series of 4-aminoethyl-3-(phenylsulfonyl)-1H-indoles, dual acting
norepinephrine reuptake inhibitors (NRIs) and 5-HT 2A receptor antagonists, is described. The …

Esophagitis is a major limiting factor in the treatment of lung cancer by radiation alone or in
combination with chemotherapy. We have previously demonstrated that intraesophageal …

Sequential structural modifications of the aryloxypropanamine template (eg, atomoxetine, 2)
led to a novel series of 1-(3-amino-2-hydroxy-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol…

To determine whether overexpression of the human MnSOD transgene protected 32D cl 3
hematopoietic progenitor cells from ionizing irradiation, 32D cl 3 cells were co‐electroporated …

Efforts to identify new selective and potent norepinephrine reuptake inhibitors (NRIs) for
multiple indications by structural modification of the previous 3-(arylamino)-3-phenylpropan-2-…

Structural modification of a virtual screening hit led to the identification of a new series of 4-[3-aryl-2,2-dioxido-2,1,3-benzothiadiazol-1(3H)-yl]-1-(methylamino)butan-2-ols
which are …