Stimulant drugs such as amphetamine are readily self-administered by humans and laboratory
animals by virtue of their actions on dopamine (DA) neurons of the midbrain. Repeated …

Rationale: A positive correlation between responding to novelty and propensity to subsequently
self-administer a drug has been reported for opioids and psychomotor stimulants but …

The effect of previous exposure to psychostimulants on the subsequent self-administration
of cocaine as well as reinstatement of this behavior by priming infusions of AMPA into the …

Repeated exposure to amphetamine (AMPH) leads to the development of behavioural
sensitization that can be demonstrated in rats as enhanced locomotor responding to and self‐…

Previous exposure to amphetamine (AMPH) in the ventral tegmental area (VTA) enhances
cocaine self-administration in a D 1 dopamine receptor-dependent manner. The present …

This study assessed the relationship between extracellular nucleus accumbens (NAc)
dopamine (DA) concentrations and sensitized locomotor activation following repeated …

The role of nucleus accumbens (NAcc) glutamate (GLU) and D1 dopamine (DA) receptor
activation in the expression of locomotor sensitization to amphetamine (AMPH) was …

Acute administration of the psychostimulant amphetamine increases extracellular levels of
dopamine (DA) by reversing the DA transporter on ascending midbrain DA neurons. In vitro …

Background: The identification of cellular targets has traditionally been the starting point for
natural product mode of action studies and has led to the understanding of many biological …

In a previous publication [1], it was reported that small molecule probes could be used in
combination with cDNA phage display libraries to identify cellular protein receptors. This proof-…