Drug addiction may be associated with a loss of executive control over maladaptive incentive
habits. We hypothesize that these incentive habits result from a pathological coupling of …

Purpose: Cockayne syndrome (CS) is a rare, autosomal-recessive disorder characterized
by microcephaly, impaired postnatal growth, and premature pathological aging. It has …

The present study investigated the involvement of dopamine-dependent mechanisms in the
anterior dorsolateral (aDLS) and posterior dorsomedial (pDMS) striatum during the early-…

Compulsive drug use and a persistent vulnerability to relapse are key features of addiction.
Imaging studies have suggested that these features may result from deficits in prefrontal …

The amygdala has traditionally been associated with fear, mediating the impact of negative
emotions on memory. However, this view does not fully encapsulate the function of the …

In the development of addiction, drug seeking becomes habitual and controlled by drug-associated
cues, and the neural locus of control over behaviour shifts from the ventral to the …

Rationale Studies in human and non-human primates demonstrate that social status is an
important determinant of cocaine reinforcement. However, it is unclear whether social rank is …

Background N-acetylcysteine (NAC) has been suggested to prevent relapse to cocaine
seeking. However, the psychological processes underlying its potential therapeutic benefit …

The alarming increase in heroin overdoses in the USA is a reminder of the need for
efficacious and novel treatments for opiate addiction. This may reflect the relatively poor …

Women are more sensitive to cocaine craving elicited by stimuli associated with relapse.
Ovarian hormones modulate cocaine craving and may therefore function as risk factors or …