User profiles for Jennifer M. Coughlin

Jennifer M Coughlin

Associate Professor, Johns Hopkins University School of Medicine
Verified email at jhmi.edu
Cited by 2706

Neuroinflammation and brain atrophy in former NFL players: an in vivo multimodal imaging pilot study

JM Coughlin, Y Wang, CA Munro, S Ma, C Yue… - Neurobiology of …, 2015 - Elsevier
There are growing concerns about potential delayed, neuropsychiatric consequences (eg,
cognitive decline, mood or anxiety disorders) of sports-related traumatic brain injury (TBI). …

PET imaging of neuroinflammation in neurological disorders

WC Kreisl, MJ Kim, JM Coughlin, ID Henter… - The Lancet …, 2020 - thelancet.com
A growing need exists for reliable in-vivo measurement of neuroinflammation to better
characterise the inflammatory processes underlying various diseases and to inform the …

Imaging of glial cell activation and white matter integrity in brains of active and recently retired national football league players

JM Coughlin, Y Wang, I Minn, N Bienko… - JAMA …, 2017 - jamanetwork.com
Importance Microglia, the resident immune cells of the central nervous system, play an
important role in the brain’s response to injury and neurodegenerative processes. It has been …

Assessing brain metabolism with 7-T proton magnetic resonance spectroscopy in patients with first-episode psychosis

AM Wang, S Pradhan, JM Coughlin, A Trivedi… - JAMA …, 2019 - jamanetwork.com
Importance The use of high-field magnetic resonance spectroscopy (MRS) in multiple brain
regions of a large population of human participants facilitates in vivo study of localized or …

Positron emission tomography studies of the glial cell marker translocator protein in patients with psychosis: a meta-analysis using individual participant data

…, GJ Matheson, K Collste, AH Ashok, JM Coughlin… - Biological …, 2018 - Elsevier
Background Accumulating evidence suggests that the immune system may be an important
target for new treatment approaches in schizophrenia. Positron emission tomography and …

Inflammatory molecular signature associated with infectious agents in psychosis

…, KL Gressitt, C Rohleder, JM Coughlin… - Schizophrenia …, 2014 - academic.oup.com
Schizophrenia (SZ) is a devastating mental condition with onset in young adulthood. The
identification of molecular biomarkers that reflect illness pathology is crucial. Recent evidence …

Regional brain distribution of translocator protein using [11C]DPA-713 PET in individuals infected with HIV

JM Coughlin, Y Wang, S Ma, C Yue, PK Kim… - Journal of …, 2014 - Springer
Imaging the brain distribution of translocator protein (TSPO), a putative biomarker for glial
cell activation and neuroinflammation, may inform management of individuals infected with …

Variability and magnitude of brain glutamate levels in schizophrenia: a meta and mega-analysis

…, JR Bustillo, AA Capizzano, JM Coughlin… - Molecular …, 2023 - nature.com
Glutamatergic dysfunction is implicated in schizophrenia pathoaetiology, but this may vary
in extent between patients. It is unclear whether inter-individual variability in glutamate is …

Sulforaphane augments glutathione and influences brain metabolites in human subjects: a clinical pilot study

…, C Higgs, T Tanaka, AM Wang, JM Coughlin… - Molecular …, 2018 - karger.com
Schizophrenia and other neuropsychiatric disorders await mechanism-associated interventions.
Excess oxidative stress is increasingly appreciated to participate in the pathophysiology …

Evaluation of two intensive care delirium screening tools for non-critically ill hospitalized patients

KJ Neufeld, MJ Hayat, JM Coughlin, AL Huberman… - Psychosomatics, 2011 - Elsevier
BACKGROUND: Delirium is a common, yet frequently under-recognized medical/psychiatric
complication for hospitalized patients, associated with substantial morbidity and mortality. …