A recent article identified five key technical determinants that make substantial contributions
to the outcome of drug R&D projects (Lessons learned from the fate of AstraZeneca’s drug …

Sodium channel inhibitors have been developed and approved as drugs to treat a variety of
indications. By contrast, sodium channel activators have not previously been considered …

The excitatory amino acid transporters (EAATs) are expressed throughout the central nervous
system, where they are responsible for the reuptake of the excitatory neurotransmitter (S)-…

Background Genome-wide scans have uncovered rare copy number variants conferring high
risk of psychiatric disorders. The 15q13.3 microdeletion is associated with a considerably …

Background: The hemizygous 22q11.2 microdeletion is a common copy number variant in
humans. The deletion confers high risk for neurodevelopmental disorders, including autism …

Despite the vast amount of research on schizophrenia and depression in the past two decades,
there have been few innovative drugs to treat these disorders. Precompetitive research …

Rationale A microdeletion at locus 15q13.3 is associated with high incidence rates of
psychopathology, including schizophrenia. A mouse model of the 15q13.3 microdeletion syndrome …

In the present study, we have elucidated the functional characteristics and mechanism of
action of methaqualone (2-methyl-3-o-tolyl-4(3H)-quinazolinone, Quaalude), an infamous …

Amphetamine (AMP), methylphenidate (MPH), and atomoxetine (ATX) are approved treatments
for ADHD, and together with nicotine (NIC), represent pharmacological agents widely …

Quantitative electroencephalography from freely moving rats is commonly used as a translational
tool for predicting drug‐effects in humans. We hypothesized that drug‐effects may be …