Objective: Hyperprolactinemia and associated side effects often occur with antipsychotics.
The authors investigated the effect of adjunctive treatment with aripiprazole on …

The early detection of potential drug‐drug interactions is an important issue of drug discovery
that has led to the development of high‐throughput screening (HTS) methods for potential …

Aims To determine the frequencies of CYP2C9 variants in the Korean population and compare
them with the frequencies in other ethnic populations. Methods Genotyping of CYP2C9*2 …

Objective This study was addressed to understand the underlying mechanism of the
substrate-dependent effect of genetic variation in SLCO1B1, which encodes OATP1B1 (organic …

There have been very limited reports on the effects of commercial fruit juices on human
CYP3A activity. Therefore, the inhibitory effects of readily available commercial fruit juices on …

Eicosanoids play an important role in various biological responses and can be used as
biomarkers for specific diseases. Therefore, we developed a highly selective, sensitive, and …

Ebastine undergoes extensive metabolism to form desalkylebastine and hydroxyebastine.
Hydroxyebastine is subsequently metabolized to carebastine. Although CYP3A4 and CYP2J2 …

The first liquid chromatography–tandem mass spectrometry (LC/MS/MS) method for determination
of acetylsalicylic acid (aspirin, ASA) and one of its major metabolites, salicylic acid (SA…

Several recent in-vitro data have revealed that CYP2C19, in addition to CYP2C9, is also
involved in the 4-methylhydroxylation of tolbutamide. We evaluated the relative contribution of …

Objective Our objective was to evaluate the effect of the CYP3A5 genotype on the
pharmacokinetics and pharmacodynamics of alprazolam in healthy volunteers. Methods Nineteen …