User profiles for John Stead

John Stead

Carleton University
Verified email at carleton.ca
Cited by 2038

Selective breeding for divergence in novelty-seeking traits: heritability and enrichment in spontaneous anxiety-related behaviors

JDH Stead, S Clinton, C Neal, J Schneider, A Jama… - Behavior genetics, 2006 - Springer
Outbred Sprague–Dawley rats can be classified as high responders (HR) or low responders
(LR) based on their levels of exploratory locomotion in a novel environment. While this …

A paradoxical association of an oxytocin receptor gene polymorphism: early-life adversity and vulnerability to depression

RJ McQuaid, OA McInnis, JD Stead… - Frontiers in …, 2013 - frontiersin.org
Several prosocial behaviors may be influenced by the hormone oxytocin. In line with this
perspective, the oxytocin receptor (OXTR) gene single nucleotide polymorphism (SNP), rs53576…

Transcriptional activation of the pathway‐specific regulator of the actinorhodin biosynthetic genes in Streptomyces coelicolor

GC Uguru, KE Stephens, JA Stead… - Molecular …, 2005 - Wiley Online Library
The Streptomyces produce a plethora of secondary metabolites including antibiotics and
undergo a complex developmental cycle. As a means of establishing the pathways that …

Perinatal iron deficiency results in altered developmental expression of genes mediating energy metabolism and neuronal morphogenesis in hippocampus

ES Carlson, JDH Stead, CR Neal, A Petryk… - …, 2007 - Wiley Online Library
The human and rat hippocampus is highly susceptible to iron deficiency (ID) during the late
fetal, early neonatal time period which is a peak time of regulated brain iron uptake and …

[PDF][PDF] Sex differences in developmental patterns of neocortical astroglia: A mouse translatome database

…, B Lacoste, F Charih, A Van Geel, J Stead… - Cell reports, 2022 - cell.com
Astroglial cells are key players in the development and maintenance of neurons and neuronal
networks. Astroglia express steroid hormone receptors and show rapid responses to …

Transcriptional profiling of the developing rat brain reveals that the most dramatic regional differentiation in gene expression occurs postpartum

JDH Stead, C Neal, F Meng, Y Wang… - Journal of …, 2006 - Soc Neuroscience
Neural development involves the expression of ensembles of regulatory genes that control
the coordinate and region-specific expression of a host of other genes, resulting in the unique …

Rapid cleavage of RNA by RNase E in the absence of 5′ monophosphate stimulation

L Kime, SS Jourdan, JA Stead… - Molecular …, 2010 - Wiley Online Library
The best characterized pathway for the initiation of mRNA degradation in Escherichia coli
involves the removal of the 5′‐terminal pyrophosphate to generate a monophosphate group …

Developmental underpinnings of differences in rodent novelty‐seeking and emotional reactivity

SM Clinton, JDH Stead, S Miller… - European Journal of …, 2011 - Wiley Online Library
Innate differences in human temperament strongly influence how individuals cope with
stress and also predispose towards specific types of psychopathology. The present study …

The PMC2NT domain of the catalytic exosome subunit Rrp6p provides the interface for binding with its cofactor Rrp47p, a nucleic acid-binding protein

JA Stead, JL Costello, MJ Livingstone… - Nucleic acids …, 2007 - academic.oup.com
The exosome complex is a key component of the cellular RNA surveillance machinery and
is required for normal 3′ end processing of many stable RNAs. Exosome activity requires …

Experiential and genetic contributions to depressive-and anxiety-like disorders: clinical and experimental studies

H Anisman, Z Merali, JDH Stead - Neuroscience & Biobehavioral Reviews, 2008 - Elsevier
Stressful events have been implicated in the precipitation of depression and anxiety. These
disorders may evolve owing to one or more of an array of neuronal changes that occur in …