Background Major depressive disorder (MDD) is the leading cause of disability worldwide.
Of individuals with MDD, 30% to 50% are unresponsive to common antidepressants, …

Paradigms used to study the response to and consequences of exposure to reward loss
have been underutilized in approaches to the psychobiology of substance use disorders. We …

Environment is known to substantially alter mental state and behaviour across the lifespan.
Biological barriers such as the blood–brain barrier (BBB) and gut barrier (GB) are major hubs …

Communication between the central nervous system and the periphery contributes to stress
responses and mood disorders. In a recent issue of Cell, Schneider et al. report that …

Despite environmental regulations in Ecuador, particularly in the Province of Azuay, the
solid waste final disposal management is still a socio-environmental problem, worsened by …

The cognitive effects of nicotine are linked to persistent modifications in extended neural
systems that regulate cognitive and emotional processes, and these changes occur during …

Previous research has shown that exposure to nicotine and other drugs of abuse stimulate
dopaminergic neurons in the mesolimbic circuit. Sustained activation of this circuit by …

Background Major depressive disorder (MDD) and bipolar disorder (BD) affect 25% people
worldwide. Available treatments targeting neurons are helpful for only 30-50% suggesting …

Chronic stress can promote loss of blood-brain barrier (BBB) integrity leading to passage of
circulating inflammatory mediators in mood-regulating brain areas and establishment of …

El estudio tradicional de los bienes del patrimonio ha dejado de ser la única vía de conocimiento.
En Ecuador y, particularmente, en la arquitectura cuencana, se han aplicado prácticas …