Studies on animal models of stress, anxiety, aggression, and sensorimotor gating have
linked specific monoamine neurotransmitter abnormalities to the cognitive and behavioral …

α 2 -Adrenergic receptors (α 2 -ARs) regulate many physiological functions and are targets
for clinically important antihypertensive and anesthetic agents. Three human and mouse …

α 2 -ARs regulate brain monoaminergic function by inhibiting neuronal firing and release of
monoamine neurotransmitters, noradrenaline (NA), serotonin (5-HT) and dopamine (DA). …

Rationale This review attempts to summarize the current status in relation to the use of
positron emission tomography (PET) imaging in the assessment of synaptic concentrations of …

The effects of levosimendan on cerebrovascular lesions and mortality were investigated in
models of primary and secondary stroke. We aimed to determine whether the effects of …

Abstract Treatment of TBI remains a major unmet medical need, with 2.5 million new cases
of traumatic brain injury (TBI) each year in Europe and 1.5 million in the USA. This single-…

The α 2 ‐adrenoceptors (ARs) are important modulators of a wide array of physiological
responses. As only a few selective compounds for the three α 2 ‐AR subtypes (α 2A , α 2B and α …

Starting from two acridine compounds identified in a high-throughput screening campaign (1
and 2, Table 1), a series of 4-aminoquinolines was synthesized and tested for their …

Amphetamines are commonly used to treat attention-deficit hyperactivity disorder, but are
also widely abused. They are employed in schizophrenia-related animal models as they …

Early studies suggest that selective α 2C -adrenoceptor (AR)-antagonism has anti-psychotic-like
and pro-cognitive properties. However, this has not been demonstrated in an animal …