Early response to antipsychotic medications is one of the most important determinants of
later symptomatic and functional outcomes in psychosis. Glutathione and glutamate have …

Importance Proton magnetic resonance spectroscopy (1H-MRS) studies indicate that altered
brain glutamatergic function may be associated with the pathophysiology of schizophrenia …

Background Functional dysconnection in schizophrenia is underwritten by a pathophysiology
of the glutamate neurotransmission that affects the excitation-inhibition balance in key …

Background: Disorganized thinking is a core feature of acute psychotic episodes that is
linked to social and vocational functioning. Several lines of evidence implicate disrupted …

Glutamatergic dysfunction is implicated in schizophrenia pathoaetiology, but this may vary
in extent between patients. It is unclear whether inter-individual variability in glutamate is …

Increased glutamatergic metabolites have been found in first episode schizophrenia. Although
abnormal neuropsychological functioning has been demonstrated to be a core feature of …

Aim Thought disorder is a core feature of schizophrenia but assessment of disordered
thinking is challenging, which may contribute to the paucity of mechanistic understanding of …

Disrupted serotonergic and glutamatergic signaling interact and contribute to the pathophysiology
of schizophrenia, which is particularly relevant for the hippocampus where diverse …

Progressive reduction in glutamatergic transmission has been proposed as an important
component of the illness trajectory of schizophrenia. Despite its popularity, to date, this notion …

Network-level dysconnectivity has been studied in positive and negative symptoms of
schizophrenia. Conceptual disorganization (CD) is a symptom subtype that predicts impaired real-…