Although Ca 2+ -stimulated cAMP response element binding protein– (CREB-) dependent
transcription has been implicated in growth, differentiation, and neuroplasticity, mechanisms …

A new orexigenic peptide called hypocretin (orexin) has recently been described in neurons
of the lateral hypothalamus and perifornical area. The medial and lateral hypothalamus …

Although the circadian time-keeping properties of the suprachiasmatic nuclei (SCN) require
gene expression, little is known about the signal transduction pathways that initiate …

Activity-regulated transcription has been implicated in adaptive plasticity in the CNS. In
many instances, this plasticity depends upon the transcription factor CREB. Precisely how …

One of the most intriguing questions in neurobiology GAP, Ca2+/DAG GTP exhange factors [GEFs],
NF1, is how neurons and synapses encode the long-term N-Ras, and B-Raf) is …

microRNAs (miRNAs) are a class of small, noncoding RNAs that regulate the stability or
translation of mRNA transcripts. Although recent work has implicated miRNAs in development …

Activity-regulated gene expression is believed to play a key role in the development and
refinement of neuronal circuitry. Nevertheless, the transcriptional networks that regulate …

Recent studies suggest that the CREB-CRE transcriptional pathway is pivotal in the formation
of some types of long-term memory. However, it has not been demonstrated that stimuli …

J. Neurochem. (2011) 116, 1–9. Abstract Since its initial characterization over 20 years ago,
there has been intense and unwavering interest in understanding the role of the …

Murine epidermal stem cells undergo alternate cycles of dormancy and activation, fuelling
tissue renewal. However, only a subset of stem cells becomes active during each round of …