Machine learning, a collection of data-analytical techniques aimed at building predictive
models from multi-dimensional datasets, is becoming integral to modern biological research. By …

Background Ketamine is reported to have rapid antidepressant effects; however, there is
limited understanding of the time-course of ketamine effects beyond a single infusion. A …

BACKGROUND: A single subanesthetic (intravenous) IV dose of ketamine might have rapid
but transient antidepressant effects in patients with treatment-resistant depression (TRD). …

Background Electroconvulsive therapy (ECT) and subanesthetic intravenous ketamine are
both currently used for treatment-resistant major depression, but the comparative …

BACKGROUND: Significant alterations in γ-aminobutyric acid (GABA) and glutamate levels
have been previously reported in symptomatic and remitted major depressive disorder (MDD)…

Objective: Posttraumatic stress disorder (PTSD) is a chronic and disabling disorder, for
which available pharmacotherapies have limited efficacy. The authors’ previous proof-of-concept …

The N-methyl-d-aspartate (NMDA) glutamate receptor antagonist ketamine may have rapid,
albeit transient, antidepressant properties. This study in patients with treatment-resistant …

Capitalizing on recent advances in resting-state functional connectivity magnetic resonance
imaging (rs-fcMRI) and the distinctive paradigm of rapid mood normalization following …

BACKGROUND Overweight and obesity are significant public health concerns that are
linked to numerous negative health consequences. Physical activity is an important lifestyle …

Quantum computers and simulators may offer significant advantages over their classical
counterparts, providing insights into quantum many-body systems and possibly improving …