Aberrant neocortical DNA methylation has been suggested to be a pathophysiological
contributor to psychotic disorders. Recently, a growth arrest and DNA-damage-inducible, beta (…

Objective Epigenetic changes are stable and long-lasting chromatin modifications that regulate
genomewide and local gene activity. The addition of two methyl groups to the 9th lysine …

Levels of acetylated Histone 3 and 4 proteins are strongly predictive of a chromatin structure
that is conducive to gene expression. In cell and animal studies, valproic acid is a potent …

Background Associations between a pro-inflammatory state and schizophrenia have been
one of the more enduring findings of psychiatry, with various lines of evidence suggesting a …

Over the last several years proteins involved in base excision repair (BER) have been
implicated in active DNA demethylation. We review the literature supporting BER as a means of …

Studies examining the epigenetic effects of nicotine are limited, but indicate that nicotine can
promote a transcriptionally permissive chromatin environment by increasing acetylation of …

OBJECTIVE: The emerging field of psychiatric epigenetics is constrained by the dearth of
research methods feasible in living patients. With this focus, we report on two separate …

Epigenetic modifications resulting in decreased gene expression is a proposed cause of
schizophrenia (Petronis, 2004; Costa et al., 2002). The deacetylation of histone 3, catalyzed by …

Early childhood trauma, including physical, sexual or emotional abuse, neglect, harm or
threat of harm, is associated with adulthood dysregulation of the immune system. Trauma can …

Background: A restrictive chromatin state has been thought to be operant in the pathophysiology
of schizophrenia. Our objective was to ascertain whether differences exist between …