Background Lamin A/C gene (LMNA) mutations frequently cause cardiac and/or skeletal
muscle diseases called striated muscle laminopathies. We created a zebrafish muscular …

Neurotoxin exposure of zebrafish larvae has been used to mimic a Parkinson’s disease (PD)
phenotype and to facilitate high-throughput drug screening. However, the vulnerability of …

Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer,
accounting for the majority of breast cancer-related death. Due to the lack of specific therapeutic …

Adult zebrafish have the ability to regenerate cells of the central nervous system. However,
few neuronal regeneration studies in adult zebrafish addressed their ability to regenerate …

All 302 neurons in the C. elegans hermaphrodite arise through asymmetric division of
neuroblasts. During embryogenesis, the C. elegans ham-1 gene is required for several …

Glial cell line‐derived neurotrophic factor (GDNF) has been reported to enhance dopaminergic
neuron survival and differentiation in vitro and in vivo, although those results are still …

Glial cell line-derived neurotrophic factor (GDNF) was initially described as important for
dopaminergic neuronal survival and is involved in many other essential functions in the central …

Zebrafish have a remarkable ability to generate new neurons throughout life and to regenerate
those neurons after injury or cell loss. These properties make zebrafish an attractive …

Background Only 35% of patients with major depressive disorder remit after first-line
treatment on medications with antidepressant properties. Furthermore, sex differences in …

In C. elegans, HAM-1 is an asymmetrically localized protein that regulates several asymmetric
neuroblast divisions. Although the protein contains a putative DNA binding domain, …