Grafts of fetal dopamine neurons survive and improve motor function in Parkinson's disease
…, S Rehncrona, B Gustavii, R Frackowiak, KL Leenders… - Science, 1990 - science.org
Neural transplantation can restore striatal dopaminergic neurotransmission in animal models
of Parkinson's disease. It has now been shown that mesencephalic dopamine neurons, …
of Parkinson's disease. It has now been shown that mesencephalic dopamine neurons, …
Blood–brain barrier dysfunction in parkinsonian midbrain in vivo
R Kortekaas, KL Leenders… - Annals of …, 2005 - Wiley Online Library
Parkinson's disease (PD) is associated with a loss of neurons from the midbrain. The cause
of PD is unknown, but it is established that certain neurotoxins can cause similar syndromes. …
of PD is unknown, but it is established that certain neurotoxins can cause similar syndromes. …
Gender differences in Parkinson's disease
…, GF Borm, WJG Oyen, KL Leenders… - Journal of Neurology …, 2007 - jnnp.bmj.com
Objective: To investigate gender differences in basic disease characteristics, motor deterioration
and nigrostriatal degeneration in Parkinson’s disease (PD). Methods: We studied 253 …
and nigrostriatal degeneration in Parkinson’s disease (PD). Methods: We studied 253 …
Human fetal dopamine neurons grafted into the striatum in two patients with severe Parkinson's disease: a detailed account of methodology and a 6-month follow-up
…, T Lindholm, A Björklund, KL Leenders… - Archives of …, 1989 - jamanetwork.com
• By using stereotaxic surgical techniques, ventral mesencephalic tissues from aborted human
fetuses of 8 to 10 weeks' gestational age were implanted unilaterally into the striata in two …
fetuses of 8 to 10 weeks' gestational age were implanted unilaterally into the striata in two …
The nigrostriatal dopaminergic system assessed in vivo by positron emission tomography in healthy volunteer subjects and patients with Parkinson's disease
• A group of healthy control subjects and patients with Parkinson's disease were investigated
using positron emission tomography and two tracers as indicators of different specific …
using positron emission tomography and two tracers as indicators of different specific …
[HTML][HTML] 5-HT modulation of dopamine release in basal ganglia in psilocybin-induced psychosis in man—a PET study with [11C] raclopride
…, P Vontobel, D Hell, KL Leenders - …, 1999 - nature.com
The modulating effects of serotonin on dopamine neurotransmission are not well understood,
particularly in acute psychotic states. Positron emission tomography was used to examine …
particularly in acute psychotic states. Positron emission tomography was used to examine …
Biomarkers of conversion to α-synucleinopathy in isolated rapid-eye-movement sleep behaviour disorder
…, A Janzen, A Kuzkina, JY Lee, KL Leenders… - The Lancet …, 2021 - thelancet.com
Patients with isolated rapid-eye-movement sleep behaviour disorder (RBD) are commonly
regarded as being in the early stages of a progressive neurodegenerative disease involving α…
regarded as being in the early stages of a progressive neurodegenerative disease involving α…
Typical cerebral metabolic patterns in neurodegenerative brain diseases
…, JCH van Oostrom, KL Leenders - Movement …, 2010 - Wiley Online Library
The differential diagnosis of neurodegenerative brain diseases on clinical grounds is difficult,
especially at an early disease stage. Several studies have found specific regional …
especially at an early disease stage. Several studies have found specific regional …
Activation of the human brain by monetary reward
…, J Missimer, RP Maguire, KL Leenders - …, 1997 - journals.lww.com
WITH the purpose of studying neural activation associated with reward processing in humans,
we measured regional cerebral blood flow in 10 right-handed healthy subjects performing …
we measured regional cerebral blood flow in 10 right-handed healthy subjects performing …
Parkinson's disease: the syndrome, the pathogenesis and pathophysiology
AL Bartels, KL Leenders - Cortex, 2009 - Elsevier
Parkinson's disease (PD) is characterised by a slowly expanding degeneration of neurons
particularly in the mesencephalon. The causes are unknown although risk factors in the …
particularly in the mesencephalon. The causes are unknown although risk factors in the …