Context In addition to trauma exposure, other factors contribute to risk for development of
posttraumatic stress disorder (PTSD) in adulthood. Both genetic and environmental factors are …

Although the fact that genetic predisposition and environmental exposures interact to shape
development and function of the human brain and, ultimately, the risk of psychiatric …

Pituitary adenylate cyclase-activating polypeptide (PACAP) is known to broadly regulate the
cellular stress response. In contrast, it is unclear if the PACAP–PAC1 receptor pathway has …

Childhood maltreatment is likely to influence fundamental biological processes and engrave
long-lasting epigenetic marks, leading to adverse health outcomes in adulthood. We aimed …

DNA methylation may mediate persistent changes in gene function following chronic stress.
To examine this hypothesis, we evaluated African American subjects matched by age and …

DNA methylation has become increasingly recognized in the etiology of psychiatric disorders.
Because brain tissue is not accessible in living humans, epigenetic studies are most often …

BACKGROUND: Women are twice as likely to develop posttraumatic stress disorder (PTSD)
than men. As shown in our previous work, the inability to suppress fear responses in safe …

Background Individual genotypes at specific loci can result in different patterns of DNA
methylation. These methylation quantitative trait loci (meQTLs) influence methylation across …

The ability to effectively regulate emotions and a secure attachment style are critical for
maintaining mental health across the life span. The experience of childhood maltreatment …

DNA methylation is an important epigenetic mechanism that has been linked to complex
diseases and is of great interest to researchers as a potential link between genome, …