Stressful events during adulthood are potent adverse environmental factors that can predispose
individuals to psychiatric disorders, including depression; however, many individuals …

There is growing evidence suggesting that early life events have long-term effects on the
neuroendocrine and behavioral developments of rodents. However, little is known about the …

In the present study, we established and characterized an animal model of vulnerability to
repeated stress. We found that control Sprague–Dawley (SD) rats showed a gradual decrease …

Background Although depression is the leading cause of disability worldwide, its pathophysiology
is poorly understood. Recent evidence has suggested that sirtuins (SIRTs) play a key …

Chronic stress-induced aberrant gene expression in the brain and subsequent dysfunctional
neuronal plasticity have been implicated in the etiology and pathophysiology of mood …

Aberrant transcriptional regulation in the brain is thought to be one of the key components of
the pathogenesis and pathophysiology of neuropsychiatric disorders. Heat shock factors (…

Hara K, Ohara M, Hayashi I, Hino T, Nishimura R, Iwasaki Y, Ogawa T, Ohyama Y, Sugiyama
M, Amano H. The green tea polyphenol (−)‐epigallocatechin gallate precipitates salivary …

Memory is formed by synapse-to-nucleus communication that leads to regulation of gene
transcription, but the identity and organizational logic of signaling pathways involved in this …

Most proteins produced in the endoplasmic reticulum (ER) of eukaryotic cells fold via disulfide
formation (oxidative folding). Oxidative folding is catalyzed by protein disulfide isomerase ( …

Lowland Anoa has become endangered due to hunting and human activity. Protection and
breeding of endangered species in a controlled environment is the best way of conservation. …