Simple and accurate quantitative analysis of 20 anti-tuberculosis drugs in human plasma using liquid chromatography–electrospray ionization–tandem mass …
HJ Kim, KA Seo, HM Kim, ES Jeong, JL Ghim… - … of pharmaceutical and …, 2015 - Elsevier
A simple and accurate liquid chromatography (LC)–tandem mass spectrometry (MS/MS)
method for the quantitation of 20 anti-tuberculosis (anti-TB) drugs in human plasma, was …
method for the quantitation of 20 anti-tuberculosis (anti-TB) drugs in human plasma, was …
[HTML][HTML] A novel non-agonist peroxisome proliferator-activated receptor γ (PPARγ) ligand UHC1 blocks PPARγ phosphorylation by cyclin-dependent kinase 5 (CDK5) …
Thiazolidinedione class of anti-diabetic drugs which are known as peroxisome proliferator-activated
receptor γ (PPARγ) ligands have been used to treat metabolic disorders, but …
receptor γ (PPARγ) ligands have been used to treat metabolic disorders, but …
Simple and accurate quantitative analysis of ten antiepileptic drugs in human plasma by liquid chromatography/tandem mass spectrometry
… Author links open overlay panel Kwon-Bok Kim a , Kyung-Ah. Seo a , Sung-Eun Kim c ,
Soo Kyung Bae a 1 , Dong-Hyun Kim a , Jae-Gook Shin a b …
Soo Kyung Bae a 1 , Dong-Hyun Kim a , Jae-Gook Shin a b …
Metabolism of 1′-and 4-hydroxymidazolam by glucuronide conjugation is largely mediated by UDP-glucuronosyltransferases 1A4, 2B4, and 2B7
KA Seo, SK Bae, YK Choi, CS Choi, KH Liu… - Drug metabolism and …, 2010 - ASPET
Midazolam undergoes oxidative hydroxylation by CYP3A to its metabolites, which are
excreted mainly as glucuronidated conjugates into the urine. In this study, we examined the …
excreted mainly as glucuronidated conjugates into the urine. In this study, we examined the …
Determination of acetylsalicylic acid and its major metabolite, salicylic acid, in human plasma using liquid chromatography–tandem mass spectrometry: application to …
SK Bae, KA Seo, EJ Jung, HS Kim… - Biomedical …, 2008 - Wiley Online Library
The first liquid chromatography–tandem mass spectrometry (LC/MS/MS) method for determination
of acetylsalicylic acid (aspirin, ASA) and one of its major metabolites, salicylic acid (SA…
of acetylsalicylic acid (aspirin, ASA) and one of its major metabolites, salicylic acid (SA…
The contributions of cytochromes P450 3A4 and 3A5 to the metabolism of the phosphodiesterase type 5 inhibitors sildenafil, udenafil, and vardenafil
HY Ku, HJ Ahn, KA Seo, H Kim, M Oh, SK Bae… - Drug Metabolism and …, 2008 - ASPET
The role of the genetically polymorphic CYP3A5 in the metabolism of CYP3A substrates is
unclear. We investigated the contributions of the CYP3A4 and CYP3A5 isoforms to the …
unclear. We investigated the contributions of the CYP3A4 and CYP3A5 isoforms to the …
The monoterpenoids citral and geraniol are moderate inhibitors of CYP2B6 hydroxylase activity
KA Seo, H Kim, HY Ku, HJ Ahn, SJ Park, SK Bae… - Chemico-biological …, 2008 - Elsevier
Monoterpenes are found in the volatile essence of flowers, plants oils, and herbal medicines.
Some are commonly used as food additives and fragrance components, and many are …
Some are commonly used as food additives and fragrance components, and many are …
In vitro assay of six UDP-glucuronosyltransferase isoforms in human liver microsomes, using cocktails of probe substrates and liquid chromatography–tandem mass …
KA Seo, HJ Kim, ES Jeong, N Abdalla, CS Choi… - Drug Metabolism and …, 2014 - ASPET
UDP-glucuronosyltransferase (UGT)–mediated drug–drug interactions are commonly
evaluated during drug development. We present a validated method for the simultaneous …
evaluated during drug development. We present a validated method for the simultaneous …
Ilaprazole, a new proton pump inhibitor, is primarily metabolized to ilaprazole sulfone by CYP3A4 and 3A5
Ilaprazole is a new proton pump inhibitor, designed for treatment of gastric ulcers, and developed
by Il-Yang Pharmaceutical Co (Seoul, Korea). It is extensively metabolised to the major …
by Il-Yang Pharmaceutical Co (Seoul, Korea). It is extensively metabolised to the major …
Cytochrome P450 2B6 catalyzes the formation of pharmacologically active sibutramine (N-{1-[1-(4-chlorophenyl) cyclobutyl]-3-methylbutyl}-N, N-dimethylamine) …
SK Bae, S Cao, KA Seo, H Kim, MJ Kim, JH Shon… - Drug metabolism and …, 2008 - ASPET
We identified cytochrome P450 (P450) isozymes that are involved in the formation of two
active sibutramine (N-{1-[1-(4-chlorophenyl)-cyclobutyl]-3-methylbutyl}-N,N-dimethylamine) …
active sibutramine (N-{1-[1-(4-chlorophenyl)-cyclobutyl]-3-methylbutyl}-N,N-dimethylamine) …