Learning and memory in monozygotic twins discordant for schizophrenia

…, EF Torrey, JM Gold, JD Ragland, LB Bigelow… - Psychological …, 1993 - cambridge.org
… symptoms were assessed by determining the presence or absence of thought disorder,
delusions, or hallucinations at or around the time of the diagnostic interview by two raters (LB

Cognitive impairments in patients with schizophrenia displaying preserved and compromised intellect

…, TE Goldberg, JM Gold, LB Bigelow… - Archives of general …, 2000 - jamanetwork.com
Background Although intellectual and neurocognitive deficits accompany schizophrenia,
there are inconsistencies in the literature concerning issues of intellectual decline, premorbid …

Neuropsychological assessment of monozygotic twins discordant for schizophrenia

…, EF Torrey, JM Gold, LB Bigelow… - Archives of general …, 1990 - jamanetwork.com
• A comparison of monozygotic twins discordant for schizophrenia controls for genetic
variance and reduces variance due to environmental circumstances, thus serving to highlight …

Expression of GABA signaling molecules KCC2, NKCC1, and GAD1 in cortical development and schizophrenia

…, C Colantuoni, MM Herman, LB Bigelow… - Journal of …, 2011 - Soc Neuroscience
GABA signaling molecules are critical for both human brain development and the
pathophysiology of schizophrenia. We examined the expression of transcripts derived from three …

Cerebral structural pathology in schizophrenia: evidence for a selective prefrontal cortical defect.

…, AR Doran, D Pickar, LB Bigelow… - The American journal …, 1988 - europepmc.org
To replicate earlier findings of central and cortical cerebral structural abnormalities and to
further examine specific prefrontal cortical irregularities in schizophrenia, the authors …

The effect of amphetamine on regional cerebral blood flow during cognitive activation in schizophrenia

…, R Coppola, S Handel, LB Bigelow… - Journal of …, 1991 - Soc Neuroscience
To explore the role of monoamines on cerebral function during specific prefrontal cognitive
activation, we conducted a double-blind placebo- controlled crossover study of the effects of …

Genetic risk of neuropsychological impairment in schizophrenia: a study of monozygotic twins discordant and concordant for the disorder

TE Goldberg, EF Torrey, JM Gold, LB Bigelow… - Schizophrenia …, 1995 - Elsevier
We used a paradigm involving monozygotic (MZ) twin pairs discordant for schizophrenia (n=20)
and concordant for schizophrenia (n=8), as well as normal MZ twin pairs (n=7) in order …

Is there cognitive decline in schizophrenia?: A cross-sectional study

…, S Nawroz, TE Goldberg, LB Bigelow… - The British Journal of …, 1994 - cambridge.org
The issue of progressive cognitive decline in patients with schizophrenia has been debated.
We performed a cross-sectional study of patients with chronic schizophrenia, aged from 18 …

Cerebral ventricular enlargement in chronic schizophrenia: An association with poor response to treatment

DR Weinberger, LB Bigelow, JE Kleinman… - Archives of General …, 1980 - jamanetwork.com
• Response to neuroleptic drug treatment in ten chronic schizophrenic patients with enlarged
cerebral ventricles was compared with ten similar patients with normal ventricles. The …

Relative risk of attention deficits in siblings of patients with schizophrenia

…, T Gscheidle, M Weirich, LB Bigelow… - American Journal of …, 2000 - Am Psychiatric Assoc
OBJECTIVE: Impaired attention has frequently been observed in studies of unaffected siblings
of patients with schizophrenia. To assess the suitability of impaired attention for use as an …