Serotonin, genetic variability, behaviour, and psychiatric disorders-a review

N Nordquist, L Oreland - Upsala journal of medical sciences, 2010 - Taylor & Francis
Brain monoamines, and serotonin in particular, have repeatedly been shown to be linked to
different psychiatric conditions such as depression, anxiety, antisocial behaviour, and …

Depression as a spreading adjustment disorder of monoaminergic neurons: a case for primary implication of the locus coeruleus

J Harro, L Oreland - Brain Research Reviews, 2001 - Elsevier
A model for the pathophysiology of depression is discussed in the context of other existing
theories. The classic monoamine theory of depression suggests that a deficit in monoamine …

Platelet monoamine oxidase, personality and alcoholism: the rise, fall and resurrection

L Oreland - Neurotoxicology, 2004 - Elsevier
The history of research on the association between platelet monoamine oxidase (MAO)
activity and personality traits, such as sensation seeking and impulsiveness, is reviewed. The …

Role of monoamine oxidase A genotype and psychosocial factors in male adolescent criminal activity

…, J Leppert, J Öhrvik, PO Alm, L Lindström, L Oreland - Biological …, 2006 - Elsevier
BACKGROUND: A number of important sociological, psychological, and biological predictors
of adolescent criminal behavior have been identified during the most recent decades. The …

Development of depression: sex and the interaction between environment and a promoter polymorphism of the serotonin transporter gene

…, J Leppert, L Lindström, L Oreland - International Journal …, 2006 - academic.oup.com
Previous research has demonstrated that a polymorphism in the serotonin transporter gene (5-HTTLPR)
and adverse psychosocial circumstances interact to predict depression. The …

Serotonin transporter polymorphism related to amygdala excitability and symptom severity in patients with social phobia

…, I Marteinsdottir, B Långström, L Oreland… - Neuroscience …, 2004 - Elsevier
A functional polymorphism in the promoter region of the human serotonin transporter (5-HTT)
gene has been related to negative affect and amygdala activity. We studied amygdala …

A link between serotonin-related gene polymorphisms, amygdala activity, and placebo-induced relief from social anxiety

…, E Jacobsson, K Wahlstedt, L Oreland… - Journal of …, 2008 - Soc Neuroscience
Placebo may yield beneficial effects that are indistinguishable from those of active medication,
but the factors underlying proneness to respond to placebo are widely unknown. Here, we …

Platelet MAO activity as a biological marker in subgroups of alcoholism

…, M Bohman, L von Knorring, L Oreland - Acta Psychiatrica …, 1985 - Wiley Online Library
In the Stockholm Adoption Study, two types of alcoholism, “Type I” and “Type II”, have been
identified on the basis of genetic predisposition. In the present study, this classification has …

Human brain contains high levels of heteroplasmy in the noncoding regions of mitochondrial DNA.

…, L Cavelier, I Eriksson, L Oreland… - Proceedings of the …, 1996 - National Acad Sciences
We have analyzed the level of intraindividual sequence variability (heteroplasmy) of mtDNA
in human brain by denaturing gradient gel electrophoresis and sequencing. Single base …

Platelet MAO activity and monoamine metabolites in cerebrospinal fluid in depressed and suicidal patients and in healthy controls

L Oreland, Å Wiberg, M Åsberg, L Träskman… - Psychiatry …, 1981 - Elsevier
Platelet monoamine oxidase (MAO) activity and cerebrospinal fluid (CSF) concentrations of
5-hydroxyindoleactic acid (5HIAA), homovanillic acid (HVA), and 4-hydroxy-3-…