Fragile X syndrome (FXS) is the most frequent inherited cause of intellectual disability and
the best-studied monogenic cause of autism. FXS results from the functional absence of the …

Sumoylation has recently emerged as a key post-translational modification involved in many,
if not all, biological processes. Small Ubiquitin-like Modifier (SUMO) polypeptides are …

Wine consumption has been popular worldwide for many centuries. Based on in vitro and in
vivo studies, a certain amount of everyday wine consumption may prevent various chronic …

Background: Bipolar disorder is characterized by cyclical alternation between mania and
depression, often comorbid with psychosis and suicide. Compared with other medications, the …

The paper deals with the study of antioxidant properties of extracts from vine seeds (Vitis
vinifera L.) using spectrometric and chromatographic techniques. Ten vine varieties (Cerason, …

Persistent organic pollutants, such as perfluorinated alkylated substances (PFASs) and
brominated flame retardants (BFRs) are widespread in the environment and most of them are …

This review is focused on the study of the effects of grape seed and skin extract (GSSE) on
human health. GSSE contains high concentrations of important polyphenolic substances with …

Nuclear orphan receptor TLX (NR2E1) functions primarily as a transcriptional repressor and
its pivotal role in brain development, glioblastoma, mental retardation and retinopathologies …

The USP19 deubiquitinase is found in a locus associated with Parkinson’s Disease (PD),
interacts with chaperonins, and promotes secretion of α-synuclein (α-syn) through the …

Since 1991 a human biomonitoring network has been established in the Czech Republic as
part of the Environmental Health Monitoring System, which was set out by the Government …