User profiles for Leon Flicker

Leon Flicker

Professor of Geriatric Medicine, WACHA, University of Western Australia
Verified email at uwa.edu.au
Cited by 35141

Global prevalence of young-onset dementia: a systematic review and meta-analysis

…, AC Bruni, R Di Lorenzo, K Smith, L Flicker… - JAMA …, 2021 - jamanetwork.com
Importance Reliable prevalence estimates are lacking for young-onset dementia (YOD), in
which symptoms of dementia start before the age of 65 years. Such estimates are needed for …

Smoking as a risk factor for Alzheimer's disease: contrasting evidence from a systematic review of case–control and cohort studies

OP Almeida, GK Hulse, D Lawrence, L Flicker - Addiction, 2002 - Wiley Online Library
Aims To investigate the risk of Alzheimer’s disease (AD) associated with smoking. Design
Meta‐analyses of case–control and cohort studies. Data source: Index Medicus–Medline (1966…

Donepezil for mild cognitive impairment

J Birks, L Flicker… - Cochrane Database …, 1996 - cochranelibrary.com
Background Problems with memory which do not meet the diagnostic criteria for dementia,
usually called mild cognitive impairment (MCI), can be the first sign of an impending dementia…

Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial

NT Lautenschlager, KL Cox, L Flicker, JK Foster… - Jama, 2008 - jamanetwork.com
Context Many observational studies have shown that physical activity reduces the risk of
cognitive decline; however, evidence from randomized trials is lacking. Objective To determine …

[PDF][PDF] Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data

…, O Vikhireva, I Sluijs, RA Scott, V Adamkova, L Flicker… - Bmj, 2014 - bmj.com
Objective To use the rs1229984 variant in the alcohol dehydrogenase 1B gene (ADH1B) as
an instrument to investigate the causal role of alcohol in cardiovascular disease. Design …

[HTML][HTML] A pooled analysis of vitamin D dose requirements for fracture prevention

…, P Lips, PJ Meunier, RA Lyons, L Flicker… - … England Journal of …, 2012 - Mass Medical Soc
Background The results of meta-analyses examining the relationship between vitamin D
supplementation and fracture reduction have been inconsistent. Methods We pooled participant-…

The Asia-Pacific clinical practice guidelines for the management of frailty

…, F Landi, LP Fried, JE Morley, B Vellas, L Flicker - Journal of the American …, 2017 - Elsevier
Objective To develop Clinical Practice Guidelines for the screening, assessment and management
of the geriatric condition of frailty. Methods An adapted Grading of Recommendations…

Falls among healthy, community-dwelling, older women: a prospective study of frequency, circumstances, consequences and prediction accuracy

K Hill, J Schwarz, L Flicker, S Carroll - … and New Zealand journal of public …, 1999 - Elsevier
Objective Most studies of falls among older people have focused on those with some
degree of balance or mobility impairment. This study aimed to establish whether falls and …

[HTML][HTML] Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic …

…, BB Worrall, SS Rich, M Matarin, PE Norman, L Flicker… - The Lancet, 2011 - thelancet.com
Background The MTHFR 677C→T polymorphism has been associated with raised homocysteine
concentration and increased risk of stroke. A previous overview showed that the effects …

Community-based exercise program reduces risk factors for falls in 65-to 75-year-old women with osteoporosis: randomized controlled trial

…, A Mallinson, L Riddell, K Kruse, JC Prior, L Flicker - Cmaj, 2002 - Can Med Assoc
Background: Exercise programs improve balance, strength and agility in elderly people and
thus may prevent falls. However, specific exercise programs that might be widely used in the …