Placebo may yield beneficial effects that are indistinguishable from those of active medication,
but the factors underlying proneness to respond to placebo are widely unknown. Here, we …

BACKGROUND: Evidence is accumulating that pharmacological blockade of the substance
P preferring neurokinin-1 (NK1) receptor reduces anxiety. This study compared the effects of …

The human startle response is modulated by emotional experiences, with startle potentiation
associated with negative affect. We used positron emission tomography with 15 O‐water to …

This study investigated the effects of anxiety on nonverbal aspects of speech using data
collected in the framework of a large study of social phobia treatment. The speech of social …

Importance Serotonin is involved in negative affect, but whether anxiety syndromes, such as
social anxiety disorder (SAD), are characterized by an overactive or underactive serotonin …

The objective was to study effects of fear on brain activity, functional connectivity and brain-behavior
relationships during symptom provocation in subjects with specific phobia. Positron …

There are few diagnostic tools for chronic musculoskeletal pain as structural imaging methods
seldom reveal pathological alterations. This is especially true for Whiplash Associated …

The amygdala is a key structure in the pathophysiology of anxiety disorders, and a putative
target for anxiolytic treatments. Selective serotonin reuptake inhibitors (SSRIs) and placebo …

Objective: The adrenal excretion of cortisol in animals is dependent on the production of
corticotropin-releasing factor in the paraventricular nucleus of the hypothalamus. The a priori …

Background: Although the amygdala is thought to be a crucial brain region for negative
affect, neuroimaging studies do not always show enhanced amygdala response to aversive …