Nonstructural protein 14 (nsp14) of coronaviruses (CoV) is important for viral replication and
transcription. The N-terminal exoribonuclease (ExoN) domain plays a proofreading role for …

Monomeric (m)Eos2 is an engineered photoactivatable fluorescent protein widely used for
super-resolution microscopy. We show that mEos2 forms oligomers at high concentrations …

The cannabinoid receptor CB2 is predominately expressed in the immune system, and
selective modulation of CB2 without the psychoactivity of CB1 has therapeutic potential in …

To date, an effective therapeutic treatment that confers strong attenuation toward
coronaviruses (CoVs) remains elusive. Of all the potential drug targets, the helicase of CoVs is …

The main protease (M pro ) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
is a key enzyme, which extensively digests CoV replicase polyproteins essential for viral …

This study aimed to obtain the first national estimate of the prevalence of autism spectrum
disorder (ASD) in Chinese children. We targeted the population of 6 to 12-year-old children for …

Human endocannabinoid systems modulate multiple physiological processes mainly through
the activation of cannabinoid receptors CB1 and CB2. Their high sequence similarity, low …

Chemokines and their receptors mediate cell migration, which influences multiple
fundamental biological processes and disease conditions such as inflammation and cancer 1 . …

CRISPR drives prokaryotic adaptation to invasive nucleic acids such as phages and
plasmids, using an RNA-mediated interference mechanism. Interference in type I CRISPR-Cas …

Cannabinoid CB 2 receptor (CB 2 R) agonists are investigated as therapeutic agents in the
clinic. However, their molecular mode-of-action is not fully understood. Here, we report the …