A disturbance in 5-HT signalling can lead to maladaptive and disruptive behavioural changes
seen in neuropsychiatric disorders, potentially by 5-HT’s role in cognitive control over …

Cocaine addiction is a major health problem that affects millions of people. Cocaine acts by
inhibiting dopamine, noradrenaline and serotonin [5-hydroxytryptamine (5-HT)] reuptake. …

Cocaine dependence is associated with orbitofrontal cortex (OFC)‐dependent cognitive
inflexibility in both humans and laboratory animals. A critical question is whether cocaine self‐…

Background: The “biological susceptibility” model posits that some individuals, by genetic
predisposition, are highly sensitive to environmental stimuli. Exposure to adverse stimuli leads …

Behavioral flexibility is a cognitive process depending on prefrontal areas allowing adaptive
responses to environmental changes. Serotonin transporter knockout (5-HTT −/− ) rodents …

Anxiety disorders are influenced by both environmental and genetic factors. A well-known
example for gene x environment interactions in psychiatry is the low activity (s) allelic variant …

A well-known example for gene x environment interactions in psychiatry is the one involving
the low activity (s) allelic variant of the serotonin transporter (5-HTT) promoter polymorphism …

Background The CLN3 disease spectrum ranges from a childhood‐onset neurodegenerative
disorder to a retina‐only disease. Given the lack of metabolic disease severity markers, it …

Environmental stimuli can influence behavior via the process of Pavlovian conditioning.
Recent genetic research suggests that some individuals are more sensitive to environmental …

Understanding the neurobiological basis underlying individual differences in conditioned
stimulus (CS) sensitivity is pertinent, given that excessive conditioned responses to CSs is a …