The translocator protein (18 kDa) (TSPO), formerly known as the peripheral benzodiazepine
receptor, is dramatically upregulated under pathologic conditions. Activated microglia are …

In order to explore whether some aspects of the autistic phenotype could be related to impairment
of the serotonergic system, we chose an animal model which mimics a potential cause …

Cellular therapy with adult stem cells appears as an opportunity for treatment of Parkinson's
disease. To validate this approach, we studied the effects of transplantation of rat adult bone-…

Two novel series of iodinated N-substituted analogs of 2β-carbomethoxy-3β-(4‘-iodophenyl)tropane
(β-CIT) and N-(3-iodoprop-(2E)-enyl)-2β-carbomethoxy-3β-(3‘,4‘-disubstituted …

Background The translocator protein (TSPO; 18 kDa), the new name of the peripheral-type
benzodiazepine receptor, is localised in mitochondria of glial cells and expressed in very low …

We studied concomitantly the level of neuroinflammation and β-amyloid (Aβ) load in the
APPswePS1dE9 transgenic mouse model of Alzheimer's disease using positron emission …

For the diagnosis and follow-up of neurodegenerative diseases, many cocaine derivatives
have been proposed as radioligands to explore the dopamine transporter. As none of them …

Serotonin transporter has a key-role in regulation of serotoninergic function, and is involved
in numerous neurodegenerative and psychiatric disorders. To obtain an efficient radioactive …

In the aim to develop an efficient fluorinated probe for positron emission tomography (PET)
exploration of the dopamine transporter (DAT), we studied several in vitro and in vivo …

The pharmacological properties of the iodinated derivative of cocaine (E)-N-(3-iodoprop-2-enyl)-2β-carbomethoxy-3β-(4′-methylphenyl)nortropane
(PE2I) were evaluated in vitro in …