Bipolar disorder (BD) is a common and highly heritable mental illness and genome-wide
association studies (GWAS) have robustly identified the first common genetic variants involved …

We conducted a genome-wide association study (GWAS) and a follow-up study of bipolar
disorder (BD), a common neuropsychiatric disorder. In the GWAS, we investigated 499,494 …

BACKGROUND: Patients with schizophrenia often suffer from cognitive dysfunction, including
impaired learning and memory. We recently demonstrated that long-term potentiation in …

Recent molecular studies have implicated common alleles of small to moderate effect and
rare alleles with larger effect sizes in the genetic architecture of schizophrenia (SCZ). It is …

Non-specific intellectual disability of autosomal recessive inheritance (NS-ARID) represents
an important fraction of severe cognitive dysfunction disorders. To date, only 10 genes have …

Background Memory performance in older persons can reflect genetic influences on cognitive
function and dementing processes. We aimed to identify genetic contributions to verbal …

Background Abnormal sex chromosome numbers in humans are observed in Turner (45,X)
and Klinefelter (47,XXY) syndromes. Both syndromes are associated with several clinical …

Context Large genomic copy number variations have been implicated as strong risk factors
for schizophrenia. However, the rarity of these events has created challenges for the …

A recent study found genome-wide significant association between common variation in the
gene neurocan (NCAN, rs1064395) and bipolar disorder (BD). In view of accumulating …

Introduction Anorectal malformations (ARM) range from mild anal to severe anorectal
anomalies. Approximately 50% are estimated to be non-syndromic with multiple familial cases …