6-[(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-N-methyl-3-pyridinecarboxamide
hydrochloride (GSK189254) is a novel histamine H 3 receptor antagonist with high …

Several transgenic mouse models of Alzheimer's disease (AD) have been developed that
exhibit β-amyloid (Aβ) neuropathology and behavioural deficits. However, not all studies have …

BACE1 is a key enzyme in the generation of Aβ, the major component of senile plaques in
the brains of Alzheimer's disease patients. We have generated transgenic mice expressing …

In this work, lactic acid recovery from clarified fermentation broths by nanofiltration was studied.
The effect of feed concentration, flow rate, transmembrane pressure and pH on flux and …

In the present study we tested the effects of the antihyperalgesic compound gabapentin on
dorsal horn neurones in adult spinal cord. Slices were taken from control and hyperalgesic …

The effects of PD 176252 [3-(1H-indol-3-yl)-N-[1-(5-methoxy-pyridin-2-yl)-cyclohexylmethyl]-2-methyl-2-[3-(nitro-phenyl)ureido]propionamide],
a nonpeptide bombesin (BB) BB 1 /BB 2 …

Background While a low CD4/CD8 ratio during HIV treatment correlates with immunosenescence,
its value in identifying patients at an increased risk for clinical events remains unclear. …

In this study we investigated the effects of maternal Δ 9 -tetrahydrocannabinol on the developing
serotonergic system. A daily dose of Δ 9 -tetrahydrocannabinol (5 mg/kg body weight) …

The cifl mutation of Saccharomyces cerevisiae (Navon et al., Biochemistry 18, 4487499,
1979) causes inability to grow on glucose and absence of catabolite inactivation. We have …

Tauopathies are a group of neurodegenerative disorders characterized by the aggregation of
the microtubule-associated protein tau. Aggregates of misfolded tau protein are believed to …