Attention deficit/hyperactivity disorder (ADHD) is a highly heritable childhood behavioral
disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute …

Autism spectrum disorder (ASD) is a highly heritable and heterogeneous group of
neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic variants …

Polygenic risk scores have shown great promise in predicting complex disease risk and will
become more accurate as training sample sizes increase. The standard approach for …

Asthma exacerbations are among the most frequent causes of hospitalization during
childhood, but the underlying mechanisms are poorly understood. We performed a genome-wide …

Regulatory and coding variants are known to be enriched with associations identified by
genome-wide association studies (GWASs) of complex disease, but their contributions to trait …

Birth weight (BW) has been shown to be influenced by both fetal and maternal factors and in
observational studies is reproducibly associated with future risk of adult metabolic diseases …

Almost all genetic risk factors for autism spectrum disorders (ASDs) can be found in the
general population, but the effects of this risk are unclear in people not ascertained for …

Birth weight within the normal range is associated with a variety of adult-onset diseases, but
the mechanisms behind these associations are poorly understood 1 . Previous genome-…

Importance Schizophrenia has a complex etiology influenced both by genetic and nongenetic
factors but disentangling these factors is difficult. Objective To estimate (1) how strongly …

Common sequence variants have recently joined rare structural polymorphisms as genetic
factors with strong evidence for association with schizophrenia. Here we extend our previous …