Background: Accumulating evidence indicates that schizophrenia is associated with brain
immune activation. While a number of reports suggest increased cytokine levels in patients …

Several studies suggest a role for kynurenic acid (KYNA) in the pathophysiology of schizophrenia.
It has been proposed that increased brain KYNA levels in schizophrenia result from a …

The G protein-coupled receptor kinase (GRK) family member protein GRK3 has been linked
to the pathophysiology of schizophrenia and bipolar disorder. Expression, as well as protein …

Increased cytokines and kynurenic acid (KYNA) levels in cerebrospinal fluid (CSF) have been
reported in patients with schizophrenia and bipolar disorder. The aim of the present study …

… Larsson, 1 Alfredo Oliveros, 3 Ida AK Nilsson, 4, 5 Simone Codeluppi, 6 Funda Orhan, 1
Maria Bhat, 7, 8 Maximilian Tufvesson-Alm, 1 Jessica Gracias, 1 Magdalena E. Kegel, 1 …

Kynurenic acid (KYNA), a metabolite of the kynurenine pathway, is emerging as a key factor
in the development of psychotic disorders. Increased levels of KYNA are found in the brain …

… e) Smoking cessation No relationship between smoking cessation and improved urine
control has been demonstrated. However, smoking-associated cough may increase the intra-…

Background The kynurenine pathway (KP) is the main route of tryptophan degradation in
the human body and generates several neuroactive and immunomodulatory metabolites. …

The brain is the most complicated structure that we know of, containing an estimated 86
billion neurons communicating through electrical and chemical processes that allow us to …

Exposure to infections in early life is considered a risk-factor for developing schizophrenia.
Recently we reported that a neonatal CNS infection with influenza A virus in mice resulted in …