Preclinical and clinical studies suggest that inflammation and vascular dysfunction contribute
to the pathogenesis of major depressive disorder (MDD). Chronic social stress alters blood…

Prevalence, symptoms, and treatment of depression suggest that major depressive
disorders (MDD) present sex differences. Social stress-induced neurovascular pathology is …

Regulation of emotions is generally associated exclusively with the brain. However, there is
evidence that peripheral systems are also involved in mood, stress vulnerability vs. resilience…

Prevalence of mental disorders, including major depressive disorder (MDD), bipolar disorder
(BD) and schizophrenia (SZ) are increasing at alarming rates in our societies. Growing …

Major depressive disorder ( MDD ) is a chronic and recurrent psychiatric condition characterized
by depressed mood, social isolation and anhedonia. It will affect 20% of individuals with …

The signals that regulate the fate of circulating monocytes remain unknown. In the present
study, we demonstrate that triggering of the NOD2 receptor by muramyl dipeptide (MDP) …

l-3,4-dihydroxyphenylalanine methyl ester hydrochloride (l-DOPA) is the gold standard for
symptomatic treatment of Parkinson's disease (PD), but long-term therapy is associated with …

Background Major depressive disorder (MDD) is the leading cause of disability worldwide.
Of individuals with MDD, 30% to 50% are unresponsive to common antidepressants, …

Monocytes are central to the physiopathology of arthritis, but their roles in progression and
resolution of the disease remain to be clarified. Using NR4A1 −/− mice, which lack patrolling …

Environment is known to substantially alter mental state and behaviour across the lifespan.
Biological barriers such as the blood–brain barrier (BBB) and gut barrier (GB) are major hubs …