[HTML][HTML] Assessing intracortical myelin in the living human brain using myelinated cortical thickness

CD Rowley, PL Bazin, CL Tardif, M Sehmbi… - Frontiers in …, 2015 - frontiersin.org
Alterations in the myelination of the cerebral cortex may underlie abnormal cortical function
in a variety of brain diseases. Here, we describe a technique for investigating changes in …

Age‐related mapping of intracortical myelin from late adolescence to middle adulthood using T1‐weighted MRI

CD Rowley, M Sehmbi, PL Bazin, CL Tardif… - Human brain …, 2017 - Wiley Online Library
Magnetic resonance imaging (MRI) studies in humans have reported that the T 1 ‐weighted
signal in the cerebral cortex follows an inverted “U” trajectory over the lifespan. Here, we …

Altered intracortical myelin staining in the dorsolateral prefrontal cortex in severe mental illness

EMR Lake, EA Steffler, CD Rowley, M Sehmbi… - European archives of …, 2017 - Springer
Imaging and postmortem studies into the severe mental illnesses of major depressive disorder
(MDD), bipolar disorder (BD), and schizophrenia (SZ) have revealed deficiencies in the …

Age-related deficits in intracortical myelination in young adults with bipolar disorder type I

M Sehmbi, CD Rowley, L Minuzzi, F Kapczinski… - Journal of Psychiatry and …, 2019 - jpn.ca
Background: Previous studies have implicated white-matter-related changes in the
pathophysiology of bipolar disorder. However, most of what is known is derived from in vivo …

Loss of age-related laminar differentiation of intracortical myelin in bipolar disorder

JS Suh, CD Rowley, M Sehmbi, CL Tardif… - Cerebral …, 2023 - academic.oup.com
Age-related changes of intracortical myelin in bipolar disorder (BD) have been observed to
deviate from the quadratic age curve observed in healthy controls (HC), but it is unclear if this …

Network properties of intracortical myelin associated with psychosocial functioning in bipolar I disorder

M Sehmbi, JS Suh, CD Rowley, L Minuzzi… - Bipolar …, 2022 - Wiley Online Library
Objective Psychosocial functioning in bipolar disorder (BD) persists even during euthymia
and has repeatedly been associated with illness progression and cognitive function. Its …

Intracortical myelination

M Sehmbi, NA Bock, BN Frey - Neurobiology of Bipolar Disorder, 2021 - Elsevier
Myelin found in the gray matter of the cortex is called intracortical myelin. Overall brain
myelination begins in utero and continues into the fifth decade of life in humans. Intracortical …

[HTML][HTML] Disruptions in T1-weighted MRI signal trajectories over age in Bipolar Disorder Type-1

CD Rowley, M Sehmbi, L Minuzzi, B Frey, N Bock - archive.aievolution.com
Methods: T 1-weighted, 1mm isotropic images were collected in subjects in the age range of
17-45 years old. Images were collected in 43 subjects diagnosed with BD type-1 and 67 …

Intracortical Myelin in Bipolar Disorder and its Relation to Cognitive Function and Peripheral Blood Markers

M Sehmbi - 2017 - macsphere.mcmaster.ca
Introduction: White matter abnormalities are routinely implicated in the pathophysiology of
Bipolar Disorder (BD). Although the cerebral cortex is primarily composed of gray matter, …

Depth-Specific Changes in Age-Related Trajectory of Intracortical Myelin in Bipolar Disorder

JS Suh, M Sehmbi, CD Rowley… - Biological …, 2021 - biologicalpsychiatryjournal.com
Background MR signal intensity related to intracortical myelin (ICM) has been shown to be
associated with specific clinical characteristics and cognitive performance in bipolar disorder (…