To examine the role of telomerase in normal and neoplastic growth, the telomerase RNA
component (mTR) was deleted from the mouse germline. mTR −/− mice lacked detectable …

Increasing evidence indicates that chromatin modifications are important regulators of mammalian
telomeres. Telomeres provide well studied paradigms of heterochromatin formation in …

Inhibition of telomerase is proposed to limit the growth of cancer cells by triggering telomere
shortening and cell death 1, 2, 3, 4, 5, 6, 7, 8, 9. Telomere maintenance by telomerase is …

… Pero a Maria Blasco ya mí nos parece que el presente de la investigación en envejecimiento
no necesita emoción extra . No vamos a invocar ensoñaciones futuristas . Es ahora …

A key process in organ homeostasis is the mobilization of stem cells out of their niches. We
show through analysis of mouse models that telomere length, as well as the catalytic …

The tumor suppressor p53 is critical in preventing cancer due to its ability to trigger proliferation
arrest and cell death upon the occurrence of a variety of stresses, most notably, DNA …

Telomeres are capping structures at the ends of eukaryotic chromosomes composed of
TTAGGG repeats bound to an array of specialized proteins 1 , 2 , 3 . Telomeres are …

Here, we describe a role for mammalian DNA methyltransferases (DNMTs) in telomere
length control. Mouse embryonic stem (ES) cells genetically deficient for DNMT1, or both …

Here, we show a role for the RB1 family proteins in directing full heterochromatin formation.
Mouse embryonic fibroblasts that are triply deficient for RB1 (retinoblastoma 1), RBL1 (…

Mammalian telomeres are formed by tandem repeats of the TTAGGG sequence, which are
progressively lost with each round of cell division. Telomere protection requires a minimal …